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- W2893564948 abstract "Chronic kidney disease is a worldwide problem, and Pb contamination is a potential risk factor. Since current biomarkers are not sensitive for the diagnosis of Pb-induced nephrotoxicity, novel biomarkers are needed. Metformin has both hypoglycaemic effects and reno-protection ability. However, its mechanism of action is unknown. We aimed to discover the early biomarkers for the diagnosis of low-level Pb-induced nephrotoxicity and understand the mechanism of reno-protection of metformin. Male Wistar rats were randomly divided into control, Pb, Pb + ML, Pb + MH and MH groups. Pb (250 ppm) was given daily via drinking water. Metformin (50 or 100 mg/kg/d) was orally administered. Urine was analysed by nuclear magnetic resonance (NMR)-based metabolomics coupled with multivariate statistical analysis, and potential biomarkers were subsequently quantified. The results showed that Pb-induced nephrotoxicity was closely correlated with the elevation of 5-aminolevulinic acid, D-lactate and guanidinoacetic acid in urine. After co-treatment with metformin, 5-aminolevulinic acid and D-lactate were decreased. This is the first demonstration that urinary 5-aminolevulinic acid, D-lactate and guanidinoacetic acid could be early biomarkers of low-level Pb-induced nephrotoxicity in rats. The reno-protection of metformin might be attributable to the reduction of D-lactate excretion." @default.
- W2893564948 created "2018-10-05" @default.
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- W2893564948 date "2018-10-01" @default.
- W2893564948 modified "2023-10-12" @default.
- W2893564948 title "Metabolic profiling of metformin treatment for low-level Pb-induced nephrotoxicity in rat urine" @default.
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- W2893564948 doi "https://doi.org/10.1038/s41598-018-32501-3" @default.
- W2893564948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167321" @default.
- W2893564948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275489" @default.
- W2893564948 hasPublicationYear "2018" @default.
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