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- W2893565166 abstract "This review discusses the chemical mechanisms of ascorbate-dependent reduction and solubilization of ferritin's ferric iron core and subsequent release of ferrous iron. The process is accelerated by low concentrations of Fe(II) that increase ferritin's intrinsic ascorbate oxidase activity, hence increasing the rate of ascorbate radical formation. These increased rates of ascorbate oxidation provide reducing equivalents (electrons) to ferritin's core and speed the core reduction rates with subsequent solubilization and release of Fe(II). Ascorbate-dependent solubilization of ferritin's iron core has consequences relating to the interpretation of 59Fe uptake sourced from 59Fe-lebelled holotransferrin into ferritin. Ascorbate-dependent reduction of the ferritin core iron solubility increases the size of ferritin's iron exchangeable pool and hence the rate and amount of exchange uptake of 59Fe into ferritin, whilst simultaneously increasing net iron release rate from ferritin. This may rationalize the inconsistency that ascorbate apparently stabilizes 59Fe ferritin and retards lysosomal ferritinolysis and whole cell 59Fe release, whilst paradoxically increasing the rate of net iron release from ferritin. This capacity of ascorbate and iron to synergise ferritin iron release has pathological significance, as it lowers the concentration at which ascorbate activates ferritin's iron release to within the physiological range (50-250 μM). These effects have relevance to inflammatory pathology and to the pro-oxidant effects of ascorbate in cancer therapy and cell death by ferroptosis." @default.
- W2893565166 created "2018-10-05" @default.
- W2893565166 creator A5066724137 @default.
- W2893565166 creator A5086036636 @default.
- W2893565166 date "2019-03-01" @default.
- W2893565166 modified "2023-10-07" @default.
- W2893565166 title "Ascorbate and ferritin interactions: Consequences for iron release in vitro and in vivo and implications for inflammation" @default.
- W2893565166 cites W1494675041 @default.
- W2893565166 cites W1494837992 @default.
- W2893565166 cites W1497554006 @default.
- W2893565166 cites W1544483469 @default.
- W2893565166 cites W1546001313 @default.
- W2893565166 cites W1547585735 @default.
- W2893565166 cites W156137099 @default.
- W2893565166 cites W1580121000 @default.
- W2893565166 cites W1582436864 @default.
- W2893565166 cites W1599899083 @default.
- W2893565166 cites W1843270395 @default.
- W2893565166 cites W1879184430 @default.
- W2893565166 cites W1913653254 @default.
- W2893565166 cites W1928298896 @default.
- W2893565166 cites W192897240 @default.
- W2893565166 cites W1935415445 @default.
- W2893565166 cites W1964472222 @default.
- W2893565166 cites W1965389900 @default.
- W2893565166 cites W1966521314 @default.
- W2893565166 cites W1966700656 @default.
- W2893565166 cites W1970885547 @default.
- W2893565166 cites W1971387061 @default.
- W2893565166 cites W1972164300 @default.
- W2893565166 cites W1973602321 @default.
- W2893565166 cites W1975851057 @default.
- W2893565166 cites W1979209619 @default.
- W2893565166 cites W1980299591 @default.
- W2893565166 cites W1980476680 @default.
- W2893565166 cites W1981182593 @default.
- W2893565166 cites W1982910588 @default.
- W2893565166 cites W1983328669 @default.
- W2893565166 cites W1986241580 @default.
- W2893565166 cites W1988842623 @default.
- W2893565166 cites W1992666480 @default.
- W2893565166 cites W1996152690 @default.
- W2893565166 cites W1996542153 @default.
- W2893565166 cites W1997070878 @default.
- W2893565166 cites W1997183854 @default.
- W2893565166 cites W1997731166 @default.
- W2893565166 cites W1999839463 @default.
- W2893565166 cites W2003228721 @default.
- W2893565166 cites W2005267953 @default.
- W2893565166 cites W2006638639 @default.
- W2893565166 cites W2007922873 @default.
- W2893565166 cites W2008215348 @default.
- W2893565166 cites W2008883395 @default.
- W2893565166 cites W2011538447 @default.
- W2893565166 cites W2012413696 @default.
- W2893565166 cites W2013230042 @default.
- W2893565166 cites W2013544053 @default.
- W2893565166 cites W2015854329 @default.
- W2893565166 cites W2015943325 @default.
- W2893565166 cites W2016379863 @default.
- W2893565166 cites W2017401413 @default.
- W2893565166 cites W2017613903 @default.
- W2893565166 cites W2018657846 @default.
- W2893565166 cites W2022452411 @default.
- W2893565166 cites W2024092039 @default.
- W2893565166 cites W2025081663 @default.
- W2893565166 cites W2025558782 @default.
- W2893565166 cites W2029143230 @default.
- W2893565166 cites W2029372864 @default.
- W2893565166 cites W2029703359 @default.
- W2893565166 cites W2031272024 @default.
- W2893565166 cites W2032926524 @default.
- W2893565166 cites W2033326835 @default.
- W2893565166 cites W2040643845 @default.
- W2893565166 cites W2043358792 @default.
- W2893565166 cites W2044449433 @default.
- W2893565166 cites W2044597069 @default.
- W2893565166 cites W2047900985 @default.
- W2893565166 cites W2049023330 @default.
- W2893565166 cites W2051729917 @default.
- W2893565166 cites W2052523921 @default.
- W2893565166 cites W2052684948 @default.
- W2893565166 cites W2054788786 @default.
- W2893565166 cites W2056007774 @default.
- W2893565166 cites W2057007574 @default.
- W2893565166 cites W2057282235 @default.
- W2893565166 cites W2058799785 @default.
- W2893565166 cites W2062742764 @default.
- W2893565166 cites W2063912018 @default.
- W2893565166 cites W2064693243 @default.
- W2893565166 cites W2066745245 @default.
- W2893565166 cites W2068774954 @default.
- W2893565166 cites W2069774708 @default.
- W2893565166 cites W2070831212 @default.
- W2893565166 cites W2073470059 @default.
- W2893565166 cites W2073799621 @default.
- W2893565166 cites W2074297250 @default.
- W2893565166 cites W2075265809 @default.