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- W2893566377 abstract "目的探讨miRNA-455-3p对HCT116结肠癌细胞迁移、侵袭的影响及机制研究。 方法采用脂质体LipofectamineTM3000将miR-455-3p mimics和miR-455-3p NC转入HCT116结肠癌细胞中，Real-time PCR检测细胞中miR-455-3p表达，MTT法检测细胞活力，划痕实验检测细胞迁移能力，Transwell实验检测细胞侵袭能力，Western blot检测细胞中基质金属蛋白酶2(matrix metalloproteinases 2，MMP2)、MMP9、磷脂酰肌醇3激酶(phosphatidylinositol 3 kinase，PI3K)/蛋白激酶B(protein kinase B，AKT)信号通路相关蛋白的表达。 结果与miR-455-3p NC组比较，miR-455-3p mimics组miR-455-3p表达量显著提高(P＜0.01)，细胞活力、迁移能力、侵袭能力均显著降低(P＜0.01)，MMP2、MMP9、PI3K及p-AKT表达量均显著下调(P＜0.01)。 结论miR-455-3p mimics可能通过阻断PI3K/AKT信号通路抑制HCT116细胞的迁移及侵袭。" @default.
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- W2893566377 date "2018-07-30" @default.
- W2893566377 modified "2023-09-23" @default.
- W2893566377 title "miRNA-455-3p对HCT116结肠癌细胞迁移、侵袭的影响及机制研究" @default.
- W2893566377 doi "https://doi.org/10.16016/j.1000-5404.201711074" @default.
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