FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893567315> ?p ?o ?g. }

• W2893567315 abstract "To evaluate the relationship between pharmacokinetic/pharmacodynamic (PK/PD) parameters and changes in susceptibility and resistance frequency of Actinobacillus pleuropneumoniae CVCC 259, a piglet tissue cage infection model was established. After A. pleuropneumoniae populations maintained at 108 CFU/mL in tissue cages, piglets were treated with various concentrations of danofloxacin once daily for 5 consecutive days by intramuscular injection. Both the concentrations of danofloxacin and the population of vial cells were calculated. Changes in susceptibility and resistance frequency were monitored. PCR amplification of quinolone resistance-determining regions (QRDRs) and DNA sequencing were performed to identify point mutations in gyrA, gyrB, parC, and parE genes. Furthermore, the susceptibility of mutants to danofloxacin and enrofloxacin was determined in the presence or absence of reserpine to assess whether the mutants were caused by efflux pumps. The MICs and resistant frequency of A. pleuropneumoniae both increased when danofloxacin concentrations fluctuated between MIC99 (0.05 μg/mL) and MPC (mutant prevention concentration, 0.4 μg/mL). As for PK/PD parameters, the resistant mutants were selected and enriched when AUC24h/MIC99 ranged from 34.68 to 148.65 h or AUC24h/MPC ranged from 4.33 to 18.58 h. Substitutions of Ser-83→Tyr or Ser-83→Phe in gyrA and Lys-53→Glu in parC were observed. The susceptibility of mutants obtained via danofloxacin treatment at 1.25 and 2.5 mg/kg were less affected by reserpine. These results demonstrate that maintaining the value of AUC24h/MPC above 18.58 h may produce a desirable antibacterial effect and protect against A. pleuropneumoniae resistance to danofloxacin." @default.
• W2893567315 created "2018-10-05" @default.
• W2893567315 creator A5003262251 @default.
• W2893567315 creator A5005661615 @default.
• W2893567315 creator A5024344221 @default.
• W2893567315 creator A5031082396 @default.
• W2893567315 creator A5035281867 @default.
• W2893567315 creator A5047195879 @default.
• W2893567315 creator A5054341736 @default.
• W2893567315 creator A5087161788 @default.
• W2893567315 date "2018-10-10" @default.
• W2893567315 modified "2023-10-09" @default.
• W2893567315 title "Pharmacokinetic/Pharmacodynamic Integration to Evaluate the Changes in Susceptibility of Actinobacillus pleuropneumoniae After Repeated Administration of Danofloxacin" @default.
• W2893567315 cites W1878824442 @default.
• W2893567315 cites W1969128660 @default.
• W2893567315 cites W1977045304 @default.
• W2893567315 cites W1982608905 @default.
• W2893567315 cites W1983076976 @default.
• W2893567315 cites W1998233277 @default.
• W2893567315 cites W2000925359 @default.
• W2893567315 cites W2009310588 @default.
• W2893567315 cites W2036138606 @default.
• W2893567315 cites W2047994548 @default.
• W2893567315 cites W2057801623 @default.
• W2893567315 cites W2059989328 @default.
• W2893567315 cites W2087294901 @default.
• W2893567315 cites W2087662606 @default.
• W2893567315 cites W2091765720 @default.
• W2893567315 cites W2092650494 @default.
• W2893567315 cites W2098727599 @default.
• W2893567315 cites W2098953174 @default.
• W2893567315 cites W2104433387 @default.
• W2893567315 cites W2108206418 @default.
• W2893567315 cites W2108310800 @default.
• W2893567315 cites W2109627571 @default.
• W2893567315 cites W2111971767 @default.
• W2893567315 cites W2116089057 @default.
• W2893567315 cites W2116940411 @default.
• W2893567315 cites W2127570357 @default.
• W2893567315 cites W2128160648 @default.
• W2893567315 cites W2130386913 @default.
• W2893567315 cites W2137784223 @default.
• W2893567315 cites W2156041474 @default.
• W2893567315 cites W2156909245 @default.
• W2893567315 cites W2171632034 @default.
• W2893567315 cites W2415502864 @default.
• W2893567315 cites W2612963338 @default.
• W2893567315 cites W2617471576 @default.
• W2893567315 doi "https://doi.org/10.3389/fmicb.2018.02445" @default.
• W2893567315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6194310" @default.
• W2893567315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30369920" @default.
• W2893567315 hasPublicationYear "2018" @default.
• W2893567315 type Work @default.
• W2893567315 sameAs 2893567315 @default.
• W2893567315 citedByCount "9" @default.
• W2893567315 countsByYear W28935673152020 @default.
• W2893567315 countsByYear W28935673152021 @default.
• W2893567315 countsByYear W28935673152022 @default.
• W2893567315 countsByYear W28935673152023 @default.
• W2893567315 crossrefType "journal-article" @default.
• W2893567315 hasAuthorship W2893567315A5003262251 @default.
• W2893567315 hasAuthorship W2893567315A5005661615 @default.
• W2893567315 hasAuthorship W2893567315A5024344221 @default.
• W2893567315 hasAuthorship W2893567315A5031082396 @default.
• W2893567315 hasAuthorship W2893567315A5035281867 @default.
• W2893567315 hasAuthorship W2893567315A5047195879 @default.
• W2893567315 hasAuthorship W2893567315A5054341736 @default.
• W2893567315 hasAuthorship W2893567315A5087161788 @default.
• W2893567315 hasBestOaLocation W28935673151 @default.
• W2893567315 hasConcept C10389963 @default.
• W2893567315 hasConcept C111113717 @default.
• W2893567315 hasConcept C112705442 @default.
• W2893567315 hasConcept C185592680 @default.
• W2893567315 hasConcept C2778512257 @default.
• W2893567315 hasConcept C2779314605 @default.
• W2893567315 hasConcept C2779906673 @default.
• W2893567315 hasConcept C2779922871 @default.
• W2893567315 hasConcept C2780861368 @default.
• W2893567315 hasConcept C2908647359 @default.
• W2893567315 hasConcept C501593827 @default.
• W2893567315 hasConcept C71924100 @default.
• W2893567315 hasConcept C86803240 @default.
• W2893567315 hasConcept C89423630 @default.
• W2893567315 hasConcept C98274493 @default.
• W2893567315 hasConcept C99454951 @default.
• W2893567315 hasConceptScore W2893567315C10389963 @default.
• W2893567315 hasConceptScore W2893567315C111113717 @default.
• W2893567315 hasConceptScore W2893567315C112705442 @default.
• W2893567315 hasConceptScore W2893567315C185592680 @default.
• W2893567315 hasConceptScore W2893567315C2778512257 @default.
• W2893567315 hasConceptScore W2893567315C2779314605 @default.
• W2893567315 hasConceptScore W2893567315C2779906673 @default.
• W2893567315 hasConceptScore W2893567315C2779922871 @default.
• W2893567315 hasConceptScore W2893567315C2780861368 @default.
• W2893567315 hasConceptScore W2893567315C2908647359 @default.
• W2893567315 hasConceptScore W2893567315C501593827 @default.
• W2893567315 hasConceptScore W2893567315C71924100 @default.
• W2893567315 hasConceptScore W2893567315C86803240 @default.
• W2893567315 hasConceptScore W2893567315C89423630 @default.
• W2893567315 hasConceptScore W2893567315C98274493 @default.

• next