Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893569544> ?p ?o ?g. }
- W2893569544 abstract "Abstract Background and Aim The relationship between Helicobacter pylori ( H. pylori ) and nonalcoholic fatty liver disease ( NAFLD ) is a matter of debate. We achieved this prospective work to study whether H. pylori infection is a risk factor for NAFLD . Methods A cohort multicenter pilot study of 369 adults without NAFLD at baseline was followed up for 2 years. Serum leptin, insulin, tumor necrosis factor‐α, adiponectin, and interleukin‐6 were measured using an enzyme‐linked immunosorbent assay ( ELISA ). Homeostasis model assessment of insulin resistance ( HOMA ‐ IR ) and leptin/adiponectin ratio ( LAR ) were calculated. Fecal H. pylori antigen was measured by ELISA . A total of 127 participants with H. pylori positive were treated and then followed up for 3 months. Results Helicobacter pylori ‐positive patients (46.3%) were associated with an increase in IR , proinflammatory cytokines, C‐reactive protein ( CRP ), LAR , NAFLD ‐liver fat score ( NAFLD ‐ LFS ), and hepatic steatosis index ( HSI ) (all P < 0.01). Multivariate analysis of NAFLD according to HSI and NAFLD ‐ LFS reported that presence of H. pylori, LAR , CRP , IL ‐6, smoking, and age (all P < 0.01) were independent risk factors for the presence of NAFLD . Multiple models adjusted for potential mediators or confounders such as metabolic, inflammatory, and biochemical factors were constructed. After therapy of H. pylori infection, there was a significant reduction in lipogenic profile, IR , leptin, LAR , CRP , proinflammatory cytokines, HSI , and NAFLD ‐ LFS , as well as, increasing HDL . Conclusion Helicobacter pylori infection was related to an increased risk of NAFLD development, through increased markers of IR , inflammatory mediators, and lipid metabolism. Moreover, its eradication can recover these NAFLD risk factors." @default.
- W2893569544 created "2018-10-05" @default.
- W2893569544 creator A5003063877 @default.
- W2893569544 creator A5007476516 @default.
- W2893569544 creator A5017944600 @default.
- W2893569544 creator A5018043808 @default.
- W2893569544 creator A5022535560 @default.
- W2893569544 creator A5027664477 @default.
- W2893569544 creator A5036009877 @default.
- W2893569544 creator A5046490612 @default.
- W2893569544 creator A5048354403 @default.
- W2893569544 creator A5061302677 @default.
- W2893569544 creator A5065574113 @default.
- W2893569544 creator A5083556624 @default.
- W2893569544 creator A5087904854 @default.
- W2893569544 creator A5091017423 @default.
- W2893569544 date "2018-09-23" @default.
- W2893569544 modified "2023-10-11" @default.
- W2893569544 title "<i>Helicobacter pylori</i> and non‐alcoholic fatty liver disease: A new enigma?" @default.
- W2893569544 cites W1540765846 @default.
- W2893569544 cites W1580642140 @default.
- W2893569544 cites W1856151485 @default.
- W2893569544 cites W1916252029 @default.
- W2893569544 cites W1963683487 @default.
- W2893569544 cites W1966551312 @default.
- W2893569544 cites W1979414872 @default.
- W2893569544 cites W1981490181 @default.
- W2893569544 cites W1984916935 @default.
- W2893569544 cites W1988870963 @default.
- W2893569544 cites W1990114569 @default.
- W2893569544 cites W1990137803 @default.
- W2893569544 cites W1996482353 @default.
- W2893569544 cites W2010450923 @default.
- W2893569544 cites W2013639572 @default.
- W2893569544 cites W2014351118 @default.
- W2893569544 cites W2025204335 @default.
- W2893569544 cites W2029772870 @default.
- W2893569544 cites W2034467418 @default.
- W2893569544 cites W2037221067 @default.
- W2893569544 cites W2041819299 @default.
- W2893569544 cites W2050340241 @default.
- W2893569544 cites W2061962106 @default.
- W2893569544 cites W2066528365 @default.
- W2893569544 cites W2078210371 @default.
- W2893569544 cites W2094236111 @default.
- W2893569544 cites W2098555833 @default.
- W2893569544 cites W2109371472 @default.
- W2893569544 cites W2119049139 @default.
- W2893569544 cites W2125258425 @default.
- W2893569544 cites W2134275212 @default.
- W2893569544 cites W2134384860 @default.
- W2893569544 cites W2136057321 @default.
- W2893569544 cites W2142844314 @default.
- W2893569544 cites W2160234571 @default.
- W2893569544 cites W2164252555 @default.
- W2893569544 cites W2167968846 @default.
- W2893569544 cites W2169674958 @default.
- W2893569544 cites W2210672989 @default.
- W2893569544 cites W2288689648 @default.
- W2893569544 cites W2292977253 @default.
- W2893569544 cites W2315193616 @default.
- W2893569544 cites W2338999473 @default.
- W2893569544 cites W2361659253 @default.
- W2893569544 cites W2366141115 @default.
- W2893569544 cites W2570938003 @default.
- W2893569544 cites W2585746397 @default.
- W2893569544 cites W2604401189 @default.
- W2893569544 cites W2612515104 @default.
- W2893569544 cites W4231544486 @default.
- W2893569544 cites W4236136546 @default.
- W2893569544 doi "https://doi.org/10.1111/hel.12537" @default.
- W2893569544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30246507" @default.
- W2893569544 hasPublicationYear "2018" @default.
- W2893569544 type Work @default.
- W2893569544 sameAs 2893569544 @default.
- W2893569544 citedByCount "45" @default.
- W2893569544 countsByYear W28935695442019 @default.
- W2893569544 countsByYear W28935695442020 @default.
- W2893569544 countsByYear W28935695442021 @default.
- W2893569544 countsByYear W28935695442022 @default.
- W2893569544 countsByYear W28935695442023 @default.
- W2893569544 crossrefType "journal-article" @default.
- W2893569544 hasAuthorship W2893569544A5003063877 @default.
- W2893569544 hasAuthorship W2893569544A5007476516 @default.
- W2893569544 hasAuthorship W2893569544A5017944600 @default.
- W2893569544 hasAuthorship W2893569544A5018043808 @default.
- W2893569544 hasAuthorship W2893569544A5022535560 @default.
- W2893569544 hasAuthorship W2893569544A5027664477 @default.
- W2893569544 hasAuthorship W2893569544A5036009877 @default.
- W2893569544 hasAuthorship W2893569544A5046490612 @default.
- W2893569544 hasAuthorship W2893569544A5048354403 @default.
- W2893569544 hasAuthorship W2893569544A5061302677 @default.
- W2893569544 hasAuthorship W2893569544A5065574113 @default.
- W2893569544 hasAuthorship W2893569544A5083556624 @default.
- W2893569544 hasAuthorship W2893569544A5087904854 @default.
- W2893569544 hasAuthorship W2893569544A5091017423 @default.
- W2893569544 hasConcept C126322002 @default.
- W2893569544 hasConcept C164027704 @default.
- W2893569544 hasConcept C2776175330 @default.
- W2893569544 hasConcept C2776409635 @default.