FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893573708> ?p ?o ?g. }

• W2893573708 abstract "Lannea edulis (Sond.) Engl. commonly known as wild grape is used traditionally for the treatment of diabetes. It is only found in Eastern and Southern Africa. Phytochemical screening, antihyperglycemic and antihyperlipidemic effects of aqueous extracts of L. edulis in alloxan induced diabetic rats were carried out. We report herein the findings of this research work. Lannea edulis crude aqueous extracts were obtained by hot infusion and evaporation method. Phytochemical screening was carried out and subsequently toxicity studies of the aqueous extracts were performed to establish the Lethal Dose 50 (LD50) in albino rats. Alloxan monohydrate was used to induce diabetes in the rats. Lannea edulis positive control group doses of 100, 300, and 500 mg/kg were administered to 3 groups for 14 days. The positive control group was administered 5 mg/kg of glibenclamide. The negative and normal control groups were administered distilled water. To determine fasting blood glucose, blood was drawn on days 0, 1, 3, 5, 7, and 14 while it was drawn on days 0 and 14 for the determination of lipids. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, cardiac glycosides, alkaloids and steroids. L. edulis diabetic positive control groups showed significant (P < 0.05) dose dependent reductions in fasting blood glucose levels. When day 0 mean blood glucose levels were compared to day 3 mean blood glucose levels of their respective groups, the 300 mg/kg L. edulis group showed a 23.3% drop and the 500 mg/kg L. edulis group showed a 52.6% drop. The 100 mg/kg L. edulis diabetic positive control group showed a 25.1% drop by day 5, the day on which it showed statistical significance (P < 0.05) compared to the diabetic control. In addition, administration of aqueous extracts of L. edulis to diabetic rats for 14 days significantly decreased (P < 0.05) the levels of serum total cholesterol, triglycerides, Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL) whilst increasing the levels of High Density Lipoprotein (HDL), when compared to the diabetic control group. It was concluded that L. edulis showed significant and dose dependent antihyperglycemic and antihyperlipidemic effects thus confirming its traditional use." @default.
• W2893573708 created "2018-10-05" @default.
• W2893573708 creator A5016577735 @default.
• W2893573708 creator A5027560133 @default.
• W2893573708 creator A5032132849 @default.
• W2893573708 creator A5036783516 @default.
• W2893573708 creator A5038486264 @default.
• W2893573708 date "2018-09-27" @default.
• W2893573708 modified "2023-10-16" @default.
• W2893573708 title "Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats" @default.
• W2893573708 cites W1969535782 @default.
• W2893573708 cites W1984847867 @default.
• W2893573708 cites W1987965490 @default.
• W2893573708 cites W1993334560 @default.
• W2893573708 cites W2000730364 @default.
• W2893573708 cites W2000999406 @default.
• W2893573708 cites W2025894699 @default.
• W2893573708 cites W2026969368 @default.
• W2893573708 cites W2035038682 @default.
• W2893573708 cites W2037887095 @default.
• W2893573708 cites W2040349573 @default.
• W2893573708 cites W2045453026 @default.
• W2893573708 cites W2045632847 @default.
• W2893573708 cites W2056066346 @default.
• W2893573708 cites W2059684897 @default.
• W2893573708 cites W2066659788 @default.
• W2893573708 cites W2080875615 @default.
• W2893573708 cites W2084324146 @default.
• W2893573708 cites W2091379521 @default.
• W2893573708 cites W2097815597 @default.
• W2893573708 cites W2099025649 @default.
• W2893573708 cites W2117545273 @default.
• W2893573708 cites W2118889799 @default.
• W2893573708 cites W2124551594 @default.
• W2893573708 cites W2124896616 @default.
• W2893573708 cites W2125779593 @default.
• W2893573708 cites W2165217972 @default.
• W2893573708 cites W2395208332 @default.
• W2893573708 cites W2471554461 @default.
• W2893573708 doi "https://doi.org/10.3389/fphar.2018.01099" @default.
• W2893573708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172360" @default.
• W2893573708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323764" @default.
• W2893573708 hasPublicationYear "2018" @default.
• W2893573708 type Work @default.
• W2893573708 sameAs 2893573708 @default.
• W2893573708 citedByCount "21" @default.
• W2893573708 countsByYear W28935737082019 @default.
• W2893573708 countsByYear W28935737082020 @default.
• W2893573708 countsByYear W28935737082021 @default.
• W2893573708 countsByYear W28935737082022 @default.
• W2893573708 countsByYear W28935737082023 @default.
• W2893573708 crossrefType "journal-article" @default.
• W2893573708 hasAuthorship W2893573708A5016577735 @default.
• W2893573708 hasAuthorship W2893573708A5027560133 @default.
• W2893573708 hasAuthorship W2893573708A5032132849 @default.
• W2893573708 hasAuthorship W2893573708A5036783516 @default.
• W2893573708 hasAuthorship W2893573708A5038486264 @default.
• W2893573708 hasBestOaLocation W28935737081 @default.
• W2893573708 hasConcept C134018914 @default.
• W2893573708 hasConcept C185592680 @default.
• W2893573708 hasConcept C195475562 @default.
• W2893573708 hasConcept C2779768347 @default.
• W2893573708 hasConcept C2781005915 @default.
• W2893573708 hasConcept C2993907526 @default.
• W2893573708 hasConcept C555293320 @default.
• W2893573708 hasConcept C556039675 @default.
• W2893573708 hasConcept C71924100 @default.
• W2893573708 hasConcept C98274493 @default.
• W2893573708 hasConceptScore W2893573708C134018914 @default.
• W2893573708 hasConceptScore W2893573708C185592680 @default.
• W2893573708 hasConceptScore W2893573708C195475562 @default.
• W2893573708 hasConceptScore W2893573708C2779768347 @default.
• W2893573708 hasConceptScore W2893573708C2781005915 @default.
• W2893573708 hasConceptScore W2893573708C2993907526 @default.
• W2893573708 hasConceptScore W2893573708C555293320 @default.
• W2893573708 hasConceptScore W2893573708C556039675 @default.
• W2893573708 hasConceptScore W2893573708C71924100 @default.
• W2893573708 hasConceptScore W2893573708C98274493 @default.
• W2893573708 hasLocation W28935737081 @default.
• W2893573708 hasLocation W28935737082 @default.
• W2893573708 hasLocation W28935737083 @default.
• W2893573708 hasLocation W28935737084 @default.
• W2893573708 hasOpenAccess W2893573708 @default.
• W2893573708 hasPrimaryLocation W28935737081 @default.
• W2893573708 hasRelatedWork W2176164960 @default.
• W2893573708 hasRelatedWork W2289085678 @default.
• W2893573708 hasRelatedWork W2321123261 @default.
• W2893573708 hasRelatedWork W2548674360 @default.
• W2893573708 hasRelatedWork W2570477294 @default.
• W2893573708 hasRelatedWork W2615050159 @default.
• W2893573708 hasRelatedWork W2963154562 @default.
• W2893573708 hasRelatedWork W3004685744 @default.
• W2893573708 hasRelatedWork W3195651762 @default.
• W2893573708 hasRelatedWork W4306247670 @default.
• W2893573708 hasVolume "9" @default.
• W2893573708 isParatext "false" @default.
• W2893573708 isRetracted "false" @default.
• W2893573708 magId "2893573708" @default.
• W2893573708 workType "article" @default.