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- W2893575501 abstract "Abstract Recognition modes of individual T-cell receptors (TCR) are well studied, but how TCR repertoires are selected during acute through persistent human virus infections is less clear. Here, we show that persistent EBV-specific clonotypes account for only 9% of unique clonotypes but are highly expanded in acute infectious mononucleosis, and have distinct antigen-specific public features that drive selection into convalescence. The other 91% of highly diverse unique clonotypes disappear and are replaced in convalescence by equally diverse “de-novo” clonotypes. These broad fluctuating repertoires lend plasticity to antigen recognition and potentially protect against T-cell clonal loss and viral escape." @default.
- W2893575501 created "2018-10-05" @default.
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- W2893575501 date "2018-09-29" @default.
- W2893575501 modified "2023-10-16" @default.
- W2893575501 title "High diversity, turnover, and structural constraints characterize TCR α and β repertoire selection" @default.
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- W2893575501 doi "https://doi.org/10.1101/428623" @default.
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