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- W2893578902 abstract "Prospective trial registration is a powerful tool to prevent reporting bias. We aimed to determine the extent to which published randomized controlled trials (RCTs) were registered and registered prospectively. We searched MEDLINE and EMBASE from January 2005 to October 2017; we also screened all articles cited by or citing included and excluded studies, and the reference lists of related reviews. We included studies that examined published RCTs and evaluated their registration status, regardless of medical specialty or language. We excluded studies that assessed RCT registration status only through mention of registration in the published RCT, without searching registries or contacting the trial investigators. Two independent reviewers blinded to the other’s work performed the selection. Following PRISMA guidelines, two investigators independently extracted data, with discrepancies resolved by consensus. We calculated pooled proportions and 95% confidence intervals using random-effects models. We analyzed 40 studies examining 8773 RCTs across a wide range of clinical specialties. The pooled proportion of registered RCTs was 53% (95% confidence interval 44% to 58%), with considerable between-study heterogeneity. A subset of 24 studies reported data on prospective registration across 5529 RCTs. The pooled proportion of prospectively registered RCTs was 20% (95% confidence interval 15% to 25%). Subgroup analyses showed that registration was higher for industry-supported and larger RCTs. A meta-regression analysis across 19 studies (5144 RCTs) showed that the proportion of registered trials significantly increased over time, with a mean proportion increase of 27%, from 25 to 52%, between 2005 and 2015. The prevalence of trial registration has increased over time, but only one in five published RCTs is prospectively registered, undermining the validity and integrity of biomedical research." @default.
- W2893578902 created "2018-10-05" @default.
- W2893578902 creator A5014513186 @default.
- W2893578902 creator A5055997493 @default.
- W2893578902 creator A5068897241 @default.
- W2893578902 date "2018-10-16" @default.
- W2893578902 modified "2023-10-09" @default.
- W2893578902 title "Registration of published randomized trials: a systematic review and meta-analysis" @default.
- W2893578902 cites W1564707045 @default.
- W2893578902 cites W1593843280 @default.
- W2893578902 cites W1774942233 @default.
- W2893578902 cites W1797378710 @default.
- W2893578902 cites W1824434740 @default.
- W2893578902 cites W1854797478 @default.
- W2893578902 cites W1897181770 @default.
- W2893578902 cites W1965992514 @default.
- W2893578902 cites W1966437236 @default.
- W2893578902 cites W1967992635 @default.
- W2893578902 cites W1970350518 @default.
- W2893578902 cites W1979123616 @default.
- W2893578902 cites W1980082054 @default.
- W2893578902 cites W1985678791 @default.
- W2893578902 cites W1987100300 @default.
- W2893578902 cites W1993595811 @default.
- W2893578902 cites W1995878636 @default.
- W2893578902 cites W1996092618 @default.
- W2893578902 cites W2002062153 @default.
- W2893578902 cites W2003075952 @default.
- W2893578902 cites W2013960597 @default.
- W2893578902 cites W2022670794 @default.
- W2893578902 cites W2022936635 @default.
- W2893578902 cites W2030683863 @default.
- W2893578902 cites W2032959055 @default.
- W2893578902 cites W2033971931 @default.
- W2893578902 cites W2050560655 @default.
- W2893578902 cites W2051411115 @default.
- W2893578902 cites W2064070613 @default.
- W2893578902 cites W2065579229 @default.
- W2893578902 cites W2066898878 @default.
- W2893578902 cites W2069222729 @default.
- W2893578902 cites W2071154758 @default.
- W2893578902 cites W2076670414 @default.
- W2893578902 cites W2086860664 @default.
- W2893578902 cites W2090073443 @default.
- W2893578902 cites W2097310500 @default.
- W2893578902 cites W2098115169 @default.
- W2893578902 cites W2103718021 @default.
- W2893578902 cites W2105988708 @default.
- W2893578902 cites W2113426096 @default.
- W2893578902 cites W2118827313 @default.
- W2893578902 cites W2122887326 @default.
- W2893578902 cites W2122908200 @default.
- W2893578902 cites W2129677975 @default.
- W2893578902 cites W2133181488 @default.
- W2893578902 cites W2135010675 @default.
- W2893578902 cites W2135393211 @default.
- W2893578902 cites W2136665212 @default.
- W2893578902 cites W2172853499 @default.
- W2893578902 cites W2180048566 @default.
- W2893578902 cites W2277874940 @default.
- W2893578902 cites W2396667326 @default.
- W2893578902 cites W2411777732 @default.
- W2893578902 cites W2412668936 @default.
- W2893578902 cites W2413031602 @default.
- W2893578902 cites W2417139677 @default.
- W2893578902 cites W2419160455 @default.
- W2893578902 cites W2428720757 @default.
- W2893578902 cites W2462778090 @default.
- W2893578902 cites W2466504929 @default.
- W2893578902 cites W2485557016 @default.
- W2893578902 cites W2490038287 @default.
- W2893578902 cites W2514040346 @default.
- W2893578902 cites W2519918803 @default.
- W2893578902 cites W2520965749 @default.
- W2893578902 cites W2521342111 @default.
- W2893578902 cites W2529322587 @default.
- W2893578902 cites W2532712064 @default.
- W2893578902 cites W2537282272 @default.
- W2893578902 cites W2550591179 @default.
- W2893578902 cites W2563126763 @default.
- W2893578902 cites W2566467546 @default.
- W2893578902 cites W2576273795 @default.
- W2893578902 cites W2581784150 @default.
- W2893578902 cites W2593325196 @default.
- W2893578902 cites W2602966423 @default.
- W2893578902 cites W2618686006 @default.
- W2893578902 cites W2728356165 @default.
- W2893578902 cites W2734976743 @default.
- W2893578902 cites W2740883756 @default.
- W2893578902 cites W2750929662 @default.
- W2893578902 cites W2769383275 @default.
- W2893578902 cites W2794138694 @default.
- W2893578902 cites W2799693072 @default.
- W2893578902 cites W4249120853 @default.
- W2893578902 doi "https://doi.org/10.1186/s12916-018-1168-6" @default.
- W2893578902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6190546" @default.
- W2893578902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30322399" @default.
- W2893578902 hasPublicationYear "2018" @default.
- W2893578902 type Work @default.
- W2893578902 sameAs 2893578902 @default.