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- W2893580067 abstract "Small nucleolar RNAs (snoRNAs) are a family of conserved nuclear RNAs that function in the modification of small nuclear RNAs (snRNAs) or ribosomal RNAs (rRNAs), or participate in the processing of rRNAs during ribosome subunit maturation. Eukaryotic DNA transcription and RNA processing produce many long noncoding RNA (lncRNA) species. Although most lncRNAs are processed like typical mRNAs to be 5' capped and 3' polyadenylated, other types of lncRNAs are stabilized from primary Pol II transcripts by alternative mechanisms. One way to generate stable lncRNAs is to co-operate with snoRNA processing to produce snoRNA-ended lncRNAs (sno-lncRNAs) and 5’ snoRNA-ended and 3’-polyadenylated lncRNAs (SPAs). Rather than silently accumulating in the nucleus, some sno-lncRNAs and SPAs are involved in the regulation of pre-rRNA transcription and alternative splicing of pre-mRNAs. Here we provide a mini-review to discuss the biogenesis and functions of these unusually processed lncRNAs." @default.
- W2893580067 created "2018-10-05" @default.
- W2893580067 creator A5071369567 @default.
- W2893580067 creator A5083528590 @default.
- W2893580067 date "2018-09-25" @default.
- W2893580067 modified "2023-10-18" @default.
- W2893580067 title "Processing and roles of snoRNA-ended long noncoding RNAs" @default.
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- W2893580067 doi "https://doi.org/10.1080/10409238.2018.1508411" @default.
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