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- W2893583276 abstract "Pancreatic Cancer (PDA) is an aggressive malignancy characterized by early spread and a high mortality. Current studies suggest that a subpopulation of cells exist within tumors, cancer stem cell (CSC), which are capable of self-renewal and give rise to unique progeny which form the major neoplastic cellular component of tumors. While CSCs constitute a small cellular subpopulation within the tumor, their resistance to chemotherapy and radiation make them an important therapeutic target for eradication. Along with distinctive phenotypic properties, CSCs possess a unique metabolic plasticity allowing them to rapidly respond and adapt to environmental changes. These cells and their progeny also display a significantly altered epigenetic state with distinctive patterns of DNA methylation. Several mechanisms of cross-talk between epigenetic and metabolic pathways in PDA exist which ultimately contribute to the observed cellular plasticity and enhanced tumorigenesis. In this review we discuss various examples of this metabolic-epigenetic interplay and how it may constitute a new avenue for therapy specifically targeting CSCs in PDA." @default.
- W2893583276 created "2018-10-05" @default.
- W2893583276 creator A5005221333 @default.
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- W2893583276 creator A5039729783 @default.
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- W2893583276 creator A5072368632 @default.
- W2893583276 creator A5085494535 @default.
- W2893583276 creator A5089427330 @default.
- W2893583276 date "2019-08-01" @default.
- W2893583276 modified "2023-10-11" @default.
- W2893583276 title "Metabolism and epigenetics of pancreatic cancer stem cells" @default.
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