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• W2893586505 abstract "Scientists have considered epigenetic modifications as a possible mechanism to deal with adverse effects of air pollution. This study aimed to compare the effect of PM10 (PM with aerodynamic diameter ≤ 10 μm) from dust storm and inversion conditions on in vitro global methylation in human peripheral blood mononuclear cells (PBMCs). PM10 was sampled in Tehran, Iran, at a point impacted with dust storm and inversion. PM toxicity was determined using the MTT assay. PBMCs were extracted from whole blood of healthy males and treated separately with a mixture of pooled PM10 from inversion and dusty conditions at concentrations of 50–300 μg/mL for 4 h. Untreated cells were used as the negative control. Moreover, 5-methylsytosine (%5-mC) and 5-hydroxymethylcytosine (%5-hmC) were measured by the enzyme-linked immunosorbent assay (ELISA) method. Daily average PM10 concentrations in dusty and inversion days were 348.40 and 220.54 μg/m3, respectively. The mean of %5-mC (2.04 ± 1.49%) was estimated 12 times more than that of %5-hmC (0.17 ± 0.11%). PM10 resulting from the both sources caused DNA hypomethylation; however, this effect from inversion (median = 3%, IQR = 2.4%) was found to be significantly more than that from dust storm (median = 1.1%, IQR = 1.38%). Moreover, particles increased %5-hmC caused by PM10, which was significantly greater when resulting from inversion (0.23 ± 0.1%) than from dust storm (0.12 ± 0.09%). Furthermore, %5-mC and %5-hmC were significantly different at different PM10 concentrations (50–300 μg/mL) so that a significant difference was observed between %5-mC and %5-hmC at extreme concentrations. Results showed that PM10 from inversion caused a significantly more global methylation than that from dust storm. It can be concluded that measurement of 5-mC and 5-hmC as epigenetic modifications in environmental studies of DNA methylation can be a good procedure to determine health effects related to PM10 exposure." @default.
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• W2893586505 date "2018-12-01" @default.
• W2893586505 modified "2023-09-23" @default.
• W2893586505 title "Effects of airborne particulate matter (PM10) from dust storm and thermal inversion on global DNA methylation in human peripheral blood mononuclear cells (PBMCs) in vitro" @default.
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• W2893586505 doi "https://doi.org/10.1016/j.atmosenv.2018.09.042" @default.
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