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- W2893589542 abstract "Abstract Although infants learn and remember, they rapidly forget, a phenomenon known as infantile amnesia. While myriad mechanisms impact this rapid forgetting, the molecular events supporting memory maintenance have yet to be explored. To explore memory mechanisms across development, we used amygdala-dependent odor-shock conditioning and focused on mechanisms important in adult memory, the AMPA receptor subunits GluA1/2 and upstream protein kinases important for trafficking AMPAR, protein kinase M zeta (PKMζ) and iota/lambda (PKCι/λ). We use odor-shock conditioning in infant rats because it is late-developing (postnatal day, PN10) and can be modulated by corticosterone during a sensitive period in early life. Our results show that memory-related molecules did not change in pups too young to learn threat (PN8) but were activated in pups old enough to learn (PN12), with increased PKMζ-PKCι/λ and GluA2 similar to that observed in adult memory, but with an uncharacteristic decrease in GluA1. This molecular signature and behavioral avoidance of the conditioned odor was recapitulated in PN8 pups injected with CORT before conditioning to precociously induce learning. Blocking learning via CORT inhibition in older pups (PN12) blocked the expression of these molecules. PN16 pups showed a more adult-like molecular cascade of increased PKMζ-PKCι/λ and GluA1–2. Finally, at all ages, zeta inhibitory peptide (ZIP) infusions into the amygdala 24 hr after conditioning blocked memory. Together, these results identify unique features of memory processes across early development: AMPAR subunits GluA1/2 and PKC isoform expression are differentially used, which may contribute to mechanisms of early life forgetting." @default.
- W2893589542 created "2018-10-05" @default.
- W2893589542 creator A5024300994 @default.
- W2893589542 creator A5037363231 @default.
- W2893589542 creator A5041958359 @default.
- W2893589542 creator A5044517146 @default.
- W2893589542 creator A5055790935 @default.
- W2893589542 date "2018-10-02" @default.
- W2893589542 modified "2023-10-17" @default.
- W2893589542 title "Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats" @default.
- W2893589542 cites W1595234035 @default.
- W2893589542 cites W1700309272 @default.
- W2893589542 cites W1937784482 @default.
- W2893589542 cites W1965632015 @default.
- W2893589542 cites W1966555773 @default.
- W2893589542 cites W1974353595 @default.
- W2893589542 cites W1974491267 @default.
- W2893589542 cites W1979637103 @default.
- W2893589542 cites W1982864908 @default.
- W2893589542 cites W1984112630 @default.
- W2893589542 cites W1985351207 @default.
- W2893589542 cites W1988193487 @default.
- W2893589542 cites W1988353820 @default.
- W2893589542 cites W1988968741 @default.
- W2893589542 cites W1994214302 @default.
- W2893589542 cites W1996396557 @default.
- W2893589542 cites W1998603073 @default.
- W2893589542 cites W2002648857 @default.
- W2893589542 cites W2002842069 @default.
- W2893589542 cites W2002877653 @default.
- W2893589542 cites W2003237927 @default.
- W2893589542 cites W2008218568 @default.
- W2893589542 cites W2009147858 @default.
- W2893589542 cites W2011200277 @default.
- W2893589542 cites W2011567013 @default.
- W2893589542 cites W2024352808 @default.
- W2893589542 cites W2025834688 @default.
- W2893589542 cites W2027679341 @default.
- W2893589542 cites W2030976437 @default.
- W2893589542 cites W2031104034 @default.
- W2893589542 cites W2040347331 @default.
- W2893589542 cites W2042808198 @default.
- W2893589542 cites W2043272276 @default.
- W2893589542 cites W2043377395 @default.
- W2893589542 cites W2043762471 @default.
- W2893589542 cites W2045013563 @default.
- W2893589542 cites W2045916207 @default.
- W2893589542 cites W2047875396 @default.
- W2893589542 cites W2048397034 @default.
- W2893589542 cites W2049741234 @default.
- W2893589542 cites W2050490808 @default.
- W2893589542 cites W2050561539 @default.
- W2893589542 cites W2053127475 @default.
- W2893589542 cites W2054895925 @default.
- W2893589542 cites W2056510630 @default.
- W2893589542 cites W2057632757 @default.
- W2893589542 cites W2061202363 @default.
- W2893589542 cites W2063400326 @default.
- W2893589542 cites W2064928064 @default.
- W2893589542 cites W2069423485 @default.
- W2893589542 cites W2074255358 @default.
- W2893589542 cites W2074944245 @default.
- W2893589542 cites W2079398298 @default.
- W2893589542 cites W2080240638 @default.
- W2893589542 cites W2080640632 @default.
- W2893589542 cites W2084732070 @default.
- W2893589542 cites W2085469499 @default.
- W2893589542 cites W2086411151 @default.
- W2893589542 cites W2092112738 @default.
- W2893589542 cites W2094397616 @default.
- W2893589542 cites W2094812248 @default.
- W2893589542 cites W2099846683 @default.
- W2893589542 cites W2100340252 @default.
- W2893589542 cites W2101192540 @default.
- W2893589542 cites W2108025834 @default.
- W2893589542 cites W2108944278 @default.
- W2893589542 cites W2117423241 @default.
- W2893589542 cites W2118072560 @default.
- W2893589542 cites W2121044460 @default.
- W2893589542 cites W2128697639 @default.
- W2893589542 cites W2133093949 @default.
- W2893589542 cites W2148156937 @default.
- W2893589542 cites W2155669081 @default.
- W2893589542 cites W2304552143 @default.
- W2893589542 cites W2317243817 @default.
- W2893589542 cites W2335818909 @default.
- W2893589542 cites W2343401612 @default.
- W2893589542 cites W2408435161 @default.
- W2893589542 cites W2415829945 @default.
- W2893589542 cites W2473545930 @default.
- W2893589542 cites W2498216132 @default.
- W2893589542 cites W2552248826 @default.
- W2893589542 cites W2561967149 @default.
- W2893589542 cites W2593981330 @default.
- W2893589542 cites W2626690396 @default.
- W2893589542 cites W2745223926 @default.
- W2893589542 cites W2758121911 @default.
- W2893589542 cites W2768847639 @default.
- W2893589542 cites W2770026575 @default.
- W2893589542 cites W2801338848 @default.