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• W2893591614 abstract "AIM: To identify a plant with potential antithyroid activity and to compare the effect ofHydro alcoholic extract of Boerhaavia diffusa (HAEBD) on L-thyroxine inducedhyperthyroidism in rats with the standard drug propylthiouracil. OBJECTIVES: Evaluation of antithyroid activity of Hydro alcoholic extract of Boerhaavia diffusaagainst l-thyroxine induced hyperthyroid model.Compare antithyroid potential with propylthiouracil. DISCUSSION: Nowadays there is considerable interest in the potential health benefits of naturalremedies such as medicinal plants and their extracts. One of these extracts is HAEBD whichhas different medicinal properties including anti-inflammatory, anticarcinogenic, plateletaggregation inhibiting, and metal chelating properties, etc (124) . The antioxidant effects of BDextract has been confirmed in different studies.(125,126) Some human clinical trials investigatedvarious effects of BD(127) and there are some experimental studies about its antidiabeticeffects (128) However, to date, there is no study on BD effects against hyperthyroidism.Therefore, in the present study, we investigated the effects of BD extracts on LT4-inducedhyperthyroidisms and organ damages in comparison with those of PTU in rats with theirpossible antioxidant effects.It has been believed that hyperthyroidism leads to oxidative damage of variousorgans and antioxidants have been reliable and favorable effects on hyperthyroidism(129).It isalso expected that BD extracts also may be showed beneficial effects on hyperthyroidismsand related organ damages.LT4-induced hypothyroidism and related liver damages werenormalized by 15 days continuous oral treatment of BD extracts 400 and 200mg/kg from 12days after first LT4 treatment. Especially BD extracts enhanced the liver antioxidant defensesystems—they dose-dependently inhibited LT4-induced increases of LPO and changes on theGSH contents, SOD, and catalase activities. These findings are considered as direct evidencesthat they have favorable ameliorating effect on the hyperthyroidisms and related organdamages induced by LT4 through antioxidant effects. The overall effects of BD extracts 400and 200 mg/kg were similar to that of PTU 10 mg/kg, in the present study. CONCLUSION: In conclusion, LT4-induced hypothyroidism and related liver damages were inhibitedby oral treatment of BD extracts 400and 200mg/kg. In addition, they also enhanced the liverantioxidant defense systems—they dose-dependently inhibited LT4-induced increases ofLPO and changes on the GSH contents, SOD, and catalase activities as direct evidences thatBD extracts have favorable ameliorating effect on the hyperthyroidisms and related organdamages induced by LT4 through antioxidant effects. BD extracts 400 and200 mg/kg showedcomparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10mg/kg.These effects of BD may help the improvement of hyperthyroidisms and accompaniedvarious organ damages, but active compound searches should be proceeding in future." @default.
• W2893591614 created "2018-10-05" @default.
• W2893591614 creator A5046273455 @default.
• W2893591614 date "2015-04-01" @default.
• W2893591614 modified "2023-09-26" @default.
• W2893591614 title "Antithyroid and Antioxidant Effects of Boerhaavia Diffusa Linn on the L-Thyroxine Induced Hyperthyroidism in Rats" @default.
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