FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893594818> ?p ?o ?g. }

• W2893594818 endingPage "390" @default.
• W2893594818 startingPage "380" @default.
• W2893594818 abstract "Objectives The generation of systemic lupus erythematosus (SLE)-related autoantibodies have been shown to be T cell dependent and antigen driven with HLA-DR restriction. In this study, the initiating antigen(s) and the mechanism of autoantibody diversification were investigated. Methods T cell epitopes (T-epitopes) of SmD1 (SmD) were mapped by T-T hybridomas generated from DR3 + AE 0 mice immunised with SmD and with SmD overlapping peptides. TCRs from the reactive hybridomas were sequenced. The core epitopes were determined. Bacterial mimics were identified by bioinformatics. Sera from DR3 + AE 0 mice immunised with SmD peptides and their mimics were analysed for their reactivity by ELISA and immunohistochemistry. Samples of blood donors were analysed for HLA-DR and autoantibody specificities. Results Multiple HLA-DR3 restricted T-epitopes within SmD were identified. Many T-T hybridomas reacted with more than one epitope. Some of them were cross-reactive with other snRNP peptides and with proteins in the Ro60/La/Ro52 complex. The reactive hybridomas used unique TCRs. Multiple T-epitope mimics were identified in commensal and environmental bacteria. Certain bacterial mimics shared both T and B cell epitopes with the related SmD peptide. Bacterial mimics induced autoantibodies to lupus-related antigens and to different tissues. HLA-DR3 + blood donors made significantly more SLE-related autoantibodies. Conclusions The unique antigenic structures of the lupus-related autoantigens provide the basis for being targeted and for T and B cell epitope spreading and autoantibody diversification with unique patterns. SLE-related autoantibodies are likely generated from responses to commensal and/or environmental microbes due to incomplete negative selection for autoreactive T cells. The production of SLE-related antibodies is inevitable in normal individuals. The findings in this investigation have significant implications in autoimmunity in general." @default.
• W2893594818 created "2018-10-05" @default.
• W2893594818 creator A5038828439 @default.
• W2893594818 creator A5055015230 @default.
• W2893594818 creator A5061770923 @default.
• W2893594818 creator A5074462331 @default.
• W2893594818 creator A5076087464 @default.
• W2893594818 creator A5080930329 @default.
• W2893594818 creator A5082134776 @default.
• W2893594818 date "2018-09-25" @default.
• W2893594818 modified "2023-10-06" @default.
• W2893594818 title "Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification" @default.
• W2893594818 cites W1573981675 @default.
• W2893594818 cites W1578414166 @default.
• W2893594818 cites W1907187258 @default.
• W2893594818 cites W1942114907 @default.
• W2893594818 cites W1950522893 @default.
• W2893594818 cites W1969781804 @default.
• W2893594818 cites W1972437174 @default.
• W2893594818 cites W2008547112 @default.
• W2893594818 cites W2049615365 @default.
• W2893594818 cites W2053555638 @default.
• W2893594818 cites W2063618409 @default.
• W2893594818 cites W2065050237 @default.
• W2893594818 cites W207238528 @default.
• W2893594818 cites W2072681359 @default.
• W2893594818 cites W2078610240 @default.
• W2893594818 cites W2084916103 @default.
• W2893594818 cites W2090022336 @default.
• W2893594818 cites W2091122779 @default.
• W2893594818 cites W2093902228 @default.
• W2893594818 cites W2099430094 @default.
• W2893594818 cites W2109779279 @default.
• W2893594818 cites W2114306477 @default.
• W2893594818 cites W2120837858 @default.
• W2893594818 cites W2123880827 @default.
• W2893594818 cites W2138985813 @default.
• W2893594818 cites W2150644622 @default.
• W2893594818 cites W2150882333 @default.
• W2893594818 cites W2157791272 @default.
• W2893594818 cites W2165184416 @default.
• W2893594818 cites W2216965477 @default.
• W2893594818 cites W2402626019 @default.
• W2893594818 cites W2548957578 @default.
• W2893594818 cites W2588969346 @default.
• W2893594818 cites W2611949705 @default.
• W2893594818 cites W2758551515 @default.
• W2893594818 cites W2783137027 @default.
• W2893594818 cites W4292232933 @default.
• W2893594818 doi "https://doi.org/10.1136/annrheumdis-2018-214125" @default.
• W2893594818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6377330" @default.
• W2893594818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254034" @default.
• W2893594818 hasPublicationYear "2018" @default.
• W2893594818 type Work @default.
• W2893594818 sameAs 2893594818 @default.
• W2893594818 citedByCount "34" @default.
• W2893594818 countsByYear W28935948182018 @default.
• W2893594818 countsByYear W28935948182020 @default.
• W2893594818 countsByYear W28935948182021 @default.
• W2893594818 countsByYear W28935948182022 @default.
• W2893594818 countsByYear W28935948182023 @default.
• W2893594818 crossrefType "journal-article" @default.
• W2893594818 hasAuthorship W2893594818A5038828439 @default.
• W2893594818 hasAuthorship W2893594818A5055015230 @default.
• W2893594818 hasAuthorship W2893594818A5061770923 @default.
• W2893594818 hasAuthorship W2893594818A5074462331 @default.
• W2893594818 hasAuthorship W2893594818A5076087464 @default.
• W2893594818 hasAuthorship W2893594818A5080930329 @default.
• W2893594818 hasAuthorship W2893594818A5082134776 @default.
• W2893594818 hasBestOaLocation W28935948182 @default.
• W2893594818 hasConcept C147483822 @default.
• W2893594818 hasConcept C159047783 @default.
• W2893594818 hasConcept C159654299 @default.
• W2893594818 hasConcept C163764329 @default.
• W2893594818 hasConcept C188280979 @default.
• W2893594818 hasConcept C195616568 @default.
• W2893594818 hasConcept C203014093 @default.
• W2893594818 hasConcept C2776090121 @default.
• W2893594818 hasConcept C2777119779 @default.
• W2893594818 hasConcept C2780130043 @default.
• W2893594818 hasConcept C71924100 @default.
• W2893594818 hasConcept C86803240 @default.
• W2893594818 hasConcept C8891405 @default.
• W2893594818 hasConceptScore W2893594818C147483822 @default.
• W2893594818 hasConceptScore W2893594818C159047783 @default.
• W2893594818 hasConceptScore W2893594818C159654299 @default.
• W2893594818 hasConceptScore W2893594818C163764329 @default.
• W2893594818 hasConceptScore W2893594818C188280979 @default.
• W2893594818 hasConceptScore W2893594818C195616568 @default.
• W2893594818 hasConceptScore W2893594818C203014093 @default.
• W2893594818 hasConceptScore W2893594818C2776090121 @default.
• W2893594818 hasConceptScore W2893594818C2777119779 @default.
• W2893594818 hasConceptScore W2893594818C2780130043 @default.
• W2893594818 hasConceptScore W2893594818C71924100 @default.
• W2893594818 hasConceptScore W2893594818C86803240 @default.
• W2893594818 hasConceptScore W2893594818C8891405 @default.
• W2893594818 hasFunder F4320310097 @default.
• W2893594818 hasFunder F4320313227 @default.

• next