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- W2893602274 endingPage "168" @default.
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- W2893602274 abstract "Diabetes can be treated with β cell replacement therapy, where a patient is transplanted with cadaveric human islets to restore glycemic control. Despite this being an effective treatment, the process of isolating islets from the pancreas requires collagenase digestion which disrupts the islet extracellular matrix (ECM) and activates anoikis-mediated apoptosis. To improve islet survival in culture and after transplantation, the islet microenvironment may be enhanced with the addition of ECM components which are lost during isolation. Furthermore, novel β cell replacement strategies, such as stem cell-derived beta cell (SCβC) treatments or alternative transplant sites and devices, could benefit from a better understanding of how β cells interact with ECM. In this mini-review, we discuss the current understanding of the pancreas and islet ECM composition and review decellularization approaches to generate a native pancreatic ECM scaffold for use in both islet and SCβC culture and transplantation." @default.
- W2893602274 created "2018-10-05" @default.
- W2893602274 creator A5049762261 @default.
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- W2893602274 date "2018-09-25" @default.
- W2893602274 modified "2023-10-11" @default.
- W2893602274 title "Rebuilding a better home for transplanted islets" @default.
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- W2893602274 doi "https://doi.org/10.1080/15476278.2018.1517509" @default.
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