Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893606935> ?p ?o ?g. }
- W2893606935 abstract "Through recent studies, the onset of acute pancreatitis in pancreatic acinar cells (PACs) and the regulatory role of PACs in severe acute pancreatitis (SAP) have been revealed. During the early stages of pancreatitis, the endoplasmic reticulum (ER) in PACs undergoes significant changes, including swelling and vacuolization. In response to an increase in the extracellular stress in ER, PACs lose their functions, leading to cell apoptosis and inflammation response. The beneficial effects of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) on SAP have been well documented in previous studies. However, the underlying mechanism of their action remains controversial. In this study, the therapeutic effects of intraperitoneally administered hAT-MSCs in a caerulein (50 μg/kg)- and lipopolysaccharide (LPS) (10 mg/kg)-co-induced SAP mouse model were evaluated. Inflammatory response and ER stress were measured in pancreatic tissue samples, and the beneficial effects were evaluated through quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunofluorescence analysis. Inflammatory response and ER stress were ameliorated following hAT-MSC injection, and the beneficial effects were observed in the absence of significant engraftment of hAT-MSCs. hAT-MSCs transfected with siRNA-targeting tumour necrosis factor-α-induced gene/protein 6 (TSG-6) were unable to inhibit ER stress and inflammation. In addition, TSG-6 from hAT-MSCs significantly suppressed ER stress-induced apoptosis and nuclear factor kappa B (NF-κB) activity in SAP model mice. TSG-6 secreted by hAT-MSCs protects PACs in SAP model mice via the inhibition of ER stress, as well as inflammatory responses. This study has revealed a new area for ER stress-targeted therapy in SAP patients." @default.
- W2893606935 created "2018-10-05" @default.
- W2893606935 creator A5015833520 @default.
- W2893606935 creator A5023527668 @default.
- W2893606935 creator A5047023135 @default.
- W2893606935 creator A5048161054 @default.
- W2893606935 creator A5049797457 @default.
- W2893606935 creator A5058761986 @default.
- W2893606935 creator A5059493453 @default.
- W2893606935 creator A5069771802 @default.
- W2893606935 creator A5089730140 @default.
- W2893606935 date "2018-09-26" @default.
- W2893606935 modified "2023-10-14" @default.
- W2893606935 title "TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice" @default.
- W2893606935 cites W1583004360 @default.
- W2893606935 cites W180375144 @default.
- W2893606935 cites W1872248581 @default.
- W2893606935 cites W1901580941 @default.
- W2893606935 cites W1928212781 @default.
- W2893606935 cites W1979573066 @default.
- W2893606935 cites W1982789137 @default.
- W2893606935 cites W1997278301 @default.
- W2893606935 cites W2000229809 @default.
- W2893606935 cites W2002439304 @default.
- W2893606935 cites W2003566728 @default.
- W2893606935 cites W2006687288 @default.
- W2893606935 cites W2021916724 @default.
- W2893606935 cites W2028702444 @default.
- W2893606935 cites W2029401145 @default.
- W2893606935 cites W2031962983 @default.
- W2893606935 cites W2034213169 @default.
- W2893606935 cites W2037536118 @default.
- W2893606935 cites W2038285398 @default.
- W2893606935 cites W2055004642 @default.
- W2893606935 cites W2063513460 @default.
- W2893606935 cites W2064776807 @default.
- W2893606935 cites W2065169927 @default.
- W2893606935 cites W2065223012 @default.
- W2893606935 cites W2066538173 @default.
- W2893606935 cites W2068511150 @default.
- W2893606935 cites W2072751167 @default.
- W2893606935 cites W2073882423 @default.
- W2893606935 cites W2078397257 @default.
- W2893606935 cites W2082373522 @default.
- W2893606935 cites W2092783134 @default.
- W2893606935 cites W2092892225 @default.
- W2893606935 cites W2093243375 @default.
- W2893606935 cites W2111513306 @default.
- W2893606935 cites W2113254662 @default.
- W2893606935 cites W2115788075 @default.
- W2893606935 cites W2144482148 @default.
- W2893606935 cites W2148429443 @default.
- W2893606935 cites W2192080449 @default.
- W2893606935 cites W2256153305 @default.
- W2893606935 cites W2328159426 @default.
- W2893606935 cites W2336113993 @default.
- W2893606935 cites W2395304983 @default.
- W2893606935 cites W2483172171 @default.
- W2893606935 cites W2560176876 @default.
- W2893606935 cites W2561209058 @default.
- W2893606935 cites W2579806171 @default.
- W2893606935 cites W2584459863 @default.
- W2893606935 cites W2603701879 @default.
- W2893606935 cites W2734253754 @default.
- W2893606935 cites W2752617071 @default.
- W2893606935 cites W2762250529 @default.
- W2893606935 cites W2767266002 @default.
- W2893606935 cites W2793194082 @default.
- W2893606935 cites W2800834657 @default.
- W2893606935 cites W2809170199 @default.
- W2893606935 cites W2989637520 @default.
- W2893606935 doi "https://doi.org/10.1186/s13287-018-1009-8" @default.
- W2893606935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158864" @default.
- W2893606935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257717" @default.
- W2893606935 hasPublicationYear "2018" @default.
- W2893606935 type Work @default.
- W2893606935 sameAs 2893606935 @default.
- W2893606935 citedByCount "31" @default.
- W2893606935 countsByYear W28936069352019 @default.
- W2893606935 countsByYear W28936069352020 @default.
- W2893606935 countsByYear W28936069352021 @default.
- W2893606935 countsByYear W28936069352022 @default.
- W2893606935 countsByYear W28936069352023 @default.
- W2893606935 crossrefType "journal-article" @default.
- W2893606935 hasAuthorship W2893606935A5015833520 @default.
- W2893606935 hasAuthorship W2893606935A5023527668 @default.
- W2893606935 hasAuthorship W2893606935A5047023135 @default.
- W2893606935 hasAuthorship W2893606935A5048161054 @default.
- W2893606935 hasAuthorship W2893606935A5049797457 @default.
- W2893606935 hasAuthorship W2893606935A5058761986 @default.
- W2893606935 hasAuthorship W2893606935A5059493453 @default.
- W2893606935 hasAuthorship W2893606935A5069771802 @default.
- W2893606935 hasAuthorship W2893606935A5089730140 @default.
- W2893606935 hasBestOaLocation W28936069351 @default.
- W2893606935 hasConcept C104317684 @default.
- W2893606935 hasConcept C127561419 @default.
- W2893606935 hasConcept C134018914 @default.
- W2893606935 hasConcept C139447449 @default.
- W2893606935 hasConcept C158617107 @default.
- W2893606935 hasConcept C171089720 @default.