FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893607518> ?p ?o ?g. }

• W2893607518 endingPage "34" @default.
• W2893607518 startingPage "25" @default.
• W2893607518 abstract "In recent years, berberine has become widely used as an effective alternative to treat dyslipidaemias; much clinical evidence has emerged. It is important to systematically and critically evaluate the existing evidence. This study aims to evaluate the efficacy and safety of berberine in patients with dyslipidaemias. A systematic review and meta-analysis of randomized clinical trials. Five electronic databases were searched up to Apr 15, 2018 to identify randomized controlled trials (RCTs) of berberine in treatment of dyslipidaemias. The outcomes were lipid profile parameters and adverse events. Study selection, data collection, risk of bias assessment, data analyses and interpretations were conducted according to the Cochrane handbook. Sixteen trials with total of 2147 participants were judged to be eligible and were included in the meta-analysis. The included trials were assessed to be of high clinical heterogeneity. The methodological quality of the majority of the trials was generally low in terms of random sequence generation, allocation concealment, blinding and incomplete outcome data. Thus, selection bias, performance bias, detection bias, attrition bias and confounding bias might exist. Meta-analysis showed that berberine significantly reduced levels of total cholesterol (TC) (MD = -0.47 mmol/l 95% CI [-0.64, -0.31], p < 0.00001), low-density lipoprotein cholesterol (LDL-C) (MD =-0.38 mmol/l 95% CI [-0.53, -0.22], p < 0.00001) and triglycerides (TG) (MD = -0.28 mmol/l 95% CI [-0.46, -0.10], p = 0.002). Berberine also increased the level of high-density lipoprotein cholesterol (HDL-C) when used alone (MD = 0.08 mmol/l 95% CI [0.03, 0.12], p = 0.001). No significant differences were found between groups in terms of incidence of adverse events (RR = 0.64 95% CI [0.31, 1.30], p = 0.22). No severe adverse effects were reported in either group. Berberine improves lipid profiles in dyslipidaemias with satisfactory safety. Nevertheless, these findings should be interpreted with caution because of the high clinical heterogeneity and high risk of bias in the included trials. Rigorous clinical trials should be carried out to provide more reliable evidence." @default.
• W2893607518 created "2018-10-05" @default.
• W2893607518 creator A5022615361 @default.
• W2893607518 creator A5031249980 @default.
• W2893607518 creator A5076061762 @default.
• W2893607518 creator A5089382995 @default.
• W2893607518 date "2018-11-01" @default.
• W2893607518 modified "2023-10-11" @default.
• W2893607518 title "Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials" @default.
• W2893607518 cites W1969395627 @default.
• W2893607518 cites W1973557710 @default.
• W2893607518 cites W1994153742 @default.
• W2893607518 cites W2034134526 @default.
• W2893607518 cites W2040982838 @default.
• W2893607518 cites W2111099202 @default.
• W2893607518 cites W2129582474 @default.
• W2893607518 cites W2134833483 @default.
• W2893607518 cites W2136157827 @default.
• W2893607518 cites W2147542963 @default.
• W2893607518 cites W2155053630 @default.
• W2893607518 cites W2274957799 @default.
• W2893607518 cites W2520504342 @default.
• W2893607518 cites W2525906202 @default.
• W2893607518 cites W2616608798 @default.
• W2893607518 cites W2619972390 @default.
• W2893607518 cites W2734471317 @default.
• W2893607518 cites W2811269521 @default.
• W2893607518 cites W4235092737 @default.
• W2893607518 cites W4236673002 @default.
• W2893607518 cites W608457234 @default.
• W2893607518 doi "https://doi.org/10.1016/j.phymed.2018.09.212" @default.
• W2893607518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30466986" @default.
• W2893607518 hasPublicationYear "2018" @default.
• W2893607518 type Work @default.
• W2893607518 sameAs 2893607518 @default.
• W2893607518 citedByCount "65" @default.
• W2893607518 countsByYear W28936075182019 @default.
• W2893607518 countsByYear W28936075182020 @default.
• W2893607518 countsByYear W28936075182021 @default.
• W2893607518 countsByYear W28936075182022 @default.
• W2893607518 countsByYear W28936075182023 @default.
• W2893607518 crossrefType "journal-article" @default.
• W2893607518 hasAuthorship W2893607518A5022615361 @default.
• W2893607518 hasAuthorship W2893607518A5031249980 @default.
• W2893607518 hasAuthorship W2893607518A5076061762 @default.
• W2893607518 hasAuthorship W2893607518A5089382995 @default.
• W2893607518 hasConcept C126322002 @default.
• W2893607518 hasConcept C168563851 @default.
• W2893607518 hasConcept C2771230 @default.
• W2893607518 hasConcept C2780116568 @default.
• W2893607518 hasConcept C2780439572 @default.
• W2893607518 hasConcept C535046627 @default.
• W2893607518 hasConcept C71924100 @default.
• W2893607518 hasConcept C77350462 @default.
• W2893607518 hasConcept C95190672 @default.
• W2893607518 hasConcept C98274493 @default.
• W2893607518 hasConceptScore W2893607518C126322002 @default.
• W2893607518 hasConceptScore W2893607518C168563851 @default.
• W2893607518 hasConceptScore W2893607518C2771230 @default.
• W2893607518 hasConceptScore W2893607518C2780116568 @default.
• W2893607518 hasConceptScore W2893607518C2780439572 @default.
• W2893607518 hasConceptScore W2893607518C535046627 @default.
• W2893607518 hasConceptScore W2893607518C71924100 @default.
• W2893607518 hasConceptScore W2893607518C77350462 @default.
• W2893607518 hasConceptScore W2893607518C95190672 @default.
• W2893607518 hasConceptScore W2893607518C98274493 @default.
• W2893607518 hasLocation W28936075181 @default.
• W2893607518 hasLocation W28936075182 @default.
• W2893607518 hasOpenAccess W2893607518 @default.
• W2893607518 hasPrimaryLocation W28936075181 @default.
• W2893607518 hasRelatedWork W2116225643 @default.
• W2893607518 hasRelatedWork W2129009178 @default.
• W2893607518 hasRelatedWork W2278275607 @default.
• W2893607518 hasRelatedWork W2767082141 @default.
• W2893607518 hasRelatedWork W2788406885 @default.
• W2893607518 hasRelatedWork W2901124172 @default.
• W2893607518 hasRelatedWork W2988302981 @default.
• W2893607518 hasRelatedWork W3047863382 @default.
• W2893607518 hasRelatedWork W3094348948 @default.
• W2893607518 hasRelatedWork W4236290651 @default.
• W2893607518 hasVolume "50" @default.
• W2893607518 isParatext "false" @default.
• W2893607518 isRetracted "false" @default.
• W2893607518 magId "2893607518" @default.
• W2893607518 workType "article" @default.