FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893610036> ?p ?o ?g. }

• W2893610036 abstract "INTRODUCTION: An ideal dosage regimen in the drug therapy of any disease is the one whichimmediately attains the desired therapeutic concentration of drug in plasma (or at the site ofaction) and maintains it constant for entire duration of treatment. This is possible throughadministration of conventional dosage form in a particular dose at a particular frequency.Thus drug may administered by variety routes in variety of dosage form. Oral route is most common and popular route of administration of drug is oral routebecause of its systemic effect, patient compliance, less expensive to manufacture. Tabletprovides high precision dosing. Tablet form is the most widely used dosage form because ofself-administration and ease in manufacturing. In most of the cases immediate on set ofaction is required as compare to conventional therapy. To achieve the rapid onset of actionand eliminate the drawbacks of conventional therapy immediate release dosage form is now adays popular and used as an alternative oral dosage form. Immediate release tablet are veryquickly after administration. Basic approach used in development is the use ofsuperdisintegrants which provide rapid disintegration of tablet after administration. Aim of the Study: The main aim of the present study is to develop a pharmaceutically equivalent, lowcost, quality improved formulation of immediate release dosage form of MetoclopramideHydrochloride 10 mg for the treatment of emesis. Evaluation and optimization of processparameters as well as finished dosage form also form part of this work comparable toinnovator product.The term “immediate release” pharmaceutical formulation includes any formulationin which the rate of release of drug from the formulation or the absorption of drug, is neitherappreciably, nor intentionally, retarded by galenic manipulations. These tablets whichdisintegrate rapidly and get dissolved to release the medicaments. It may be provided for byway of an appropriate pharmaceutically acceptable diluent or carrier, which diluent or carrierdoes not prolong, to an appreciable extent, the rate of drug release or absorption. Objective: The main objective of this study was:A. To formulate and evaluate immediate release of Metoclopramidehydrochloride tablets.B. To study the release profile of the dosage form and to compare their drugrelease profiles with the innovator.C. To determine the best fit dissolution profile for dosage form.D. To study the stability of dosage form. SUMMARY: The present study was under taken to formulate and evaluate the immediate releasetablets of Metoclopramide hydrochloride by using wet granulation technique with variousdisintegerants. The study involves pre-formulation ofdrug and excipients, formulation,evaluation and stability studies.Nine formulations of metoclopramide were prepared by using various disintegerant indifferent concentration. The optimized formulation was selected according to the result foundfrom the evaluation parameter of each formulation. Estimation of drug was carried outspectrometrically by UV method. Pre-formulation study involving FTIR showed nointeraction between drug and excipients.The selected drug Metoclopramide was taken and formulated with differentconcentration of starch, talc and sodium starch glycolate. The tablets were prepared by wetgranulation method and then it is punched after subjecting the blend to pre-compressionparameters like Angle of repose (25.070), Bulk density (0.63gm/cm), Tappeddensity(0.72g/cm3), Carr’s Index (12.5%), Hausner ratio (1.14). The results obtained weresatisfactory. The Post compression parameters like Hardness (3.7kg/cm2), Weight variation(101.6%), Friability (0.69%), Drug content analysis (99.86%), Disintegeration time (30sec)and In-vitro dissolution studies (99.10 at 15 min) were also carried out and tabulated. Amongall these formulations F7 was selected as optimized formulation.The selected optimized formulation was characterized with stability studies. Thesetablets were subjected to pre-compression parameters and post-compression parameters.These results were compared with the predetermined optimized formulation results. Theformulation was found to be stable.The prepared in-vitro dissolution studies of prepared immediate release tablet werecompared with that of marketed formulations and were found to be better than them. CONCLUSION: The Present study was conducted to formulate and evaluate the immediate releasetablet of Metoclopramide hydrochloride. Pre-formulation study was carried out initially withstudy of selection of superdisintegrants was done and different formulations were preparedusing sodium starch glycolate and starch as disintegerants. Immediate release tablet ofMetoclopramide hydrochloride was prepared by wet granulation method. The tabletdisintegrated rapidly and has an acceptable friability and hardness. In vitro drug release fromthe tablets shows significantly improved drug dissolution. Hence it could be concluded thatthe superdisintegrant based on immediate release tablet of Metoclopramide hydrochloridewould be quite effective in emesis, providing quick onset of action on administration." @default.
• W2893610036 created "2018-10-05" @default.
• W2893610036 creator A5063634785 @default.
• W2893610036 date "2017-04-01" @default.
• W2893610036 modified "2023-09-23" @default.
• W2893610036 title "Formulation and Evaluation of Immediate Release Tablets of Metoclopramide Hydrochloride" @default.
• W2893610036 hasPublicationYear "2017" @default.
• W2893610036 type Work @default.
• W2893610036 sameAs 2893610036 @default.
• W2893610036 citedByCount "0" @default.
• W2893610036 crossrefType "dissertation" @default.
• W2893610036 hasAuthorship W2893610036A5063634785 @default.
• W2893610036 hasConcept C111919701 @default.
• W2893610036 hasConcept C2776093070 @default.
• W2893610036 hasConcept C2776473838 @default.
• W2893610036 hasConcept C2777056448 @default.
• W2893610036 hasConcept C2777288759 @default.
• W2893610036 hasConcept C2780035454 @default.
• W2893610036 hasConcept C34974158 @default.
• W2893610036 hasConcept C41008148 @default.
• W2893610036 hasConcept C46821324 @default.
• W2893610036 hasConcept C71924100 @default.
• W2893610036 hasConcept C77281830 @default.
• W2893610036 hasConcept C98274493 @default.
• W2893610036 hasConceptScore W2893610036C111919701 @default.
• W2893610036 hasConceptScore W2893610036C2776093070 @default.
• W2893610036 hasConceptScore W2893610036C2776473838 @default.
• W2893610036 hasConceptScore W2893610036C2777056448 @default.
• W2893610036 hasConceptScore W2893610036C2777288759 @default.
• W2893610036 hasConceptScore W2893610036C2780035454 @default.
• W2893610036 hasConceptScore W2893610036C34974158 @default.
• W2893610036 hasConceptScore W2893610036C41008148 @default.
• W2893610036 hasConceptScore W2893610036C46821324 @default.
• W2893610036 hasConceptScore W2893610036C71924100 @default.
• W2893610036 hasConceptScore W2893610036C77281830 @default.
• W2893610036 hasConceptScore W2893610036C98274493 @default.
• W2893610036 hasLocation W28936100361 @default.
• W2893610036 hasOpenAccess W2893610036 @default.
• W2893610036 hasPrimaryLocation W28936100361 @default.
• W2893610036 hasRelatedWork W2185001111 @default.
• W2893610036 hasRelatedWork W2188396660 @default.
• W2893610036 hasRelatedWork W2241364002 @default.
• W2893610036 hasRelatedWork W2615010325 @default.
• W2893610036 hasRelatedWork W2782848235 @default.
• W2893610036 hasRelatedWork W2783702726 @default.
• W2893610036 hasRelatedWork W2783869521 @default.
• W2893610036 hasRelatedWork W2784206955 @default.
• W2893610036 hasRelatedWork W2784215577 @default.
• W2893610036 hasRelatedWork W2791140351 @default.
• W2893610036 hasRelatedWork W2809309104 @default.
• W2893610036 hasRelatedWork W2809776059 @default.
• W2893610036 hasRelatedWork W2888640466 @default.
• W2893610036 hasRelatedWork W3088006828 @default.
• W2893610036 hasRelatedWork W3146910509 @default.
• W2893610036 hasRelatedWork W1869379909 @default.
• W2893610036 hasRelatedWork W1948470486 @default.
• W2893610036 hasRelatedWork W2183383646 @default.
• W2893610036 hasRelatedWork W2185653705 @default.
• W2893610036 hasRelatedWork W2555262021 @default.
• W2893610036 isParatext "false" @default.
• W2893610036 isRetracted "false" @default.
• W2893610036 magId "2893610036" @default.
• W2893610036 workType "dissertation" @default.