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• W2893614331 abstract "Method validation is a cornerstone on which biomarker development and utilization rest. However, given the abundance of biomarker candidates that are being identified and characterized, validation of these entities for the use in nonclinical studies can be complex. The objective of this continuing education course was to review current practices and challenges encountered during the validation of methods for the analysis of novel biomarkers. Additionally, the importance of biological validation and correlation with pathology end points for biomarker candidates was discussed. This article is a summary of the materials presented at the 36th Annual Symposium of the Society of Toxicologic Pathology for a continuing education course titled “Current Practices and Challenges in Method Validation.” The speakers were subject-matter experts in the validation of quantitative mass spectrometry, multiplex binding assays, biological biomarkers, and immunophenotyping and anatomic and clinical pathology considerations in biomarker qualification." @default.
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• W2893614331 date "2018-09-25" @default.
• W2893614331 modified "2023-09-27" @default.
• W2893614331 title "Current Practices and Challenges in Method Validation" @default.
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• W2893614331 doi "https://doi.org/10.1177/0192623318801571" @default.
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