FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893614816> ?p ?o ?g. }

• W2893614816 abstract "Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory responses. We found that ALWPs (500 mg/ml) inhibited lipopolysaccharide (LPS)-induced proinflammatory cytokine IL-1β mRNA levels in BV2 microglial cells but not primary astrocytes. ALWPs significantly reduced LPS-induced cell-surface levels of TLR4 to alter neuroinflammation. An examination of the molecular mechanisms by which ALWPs regulate the LPS-induced proinflammatory response revealed that ALWPs significantly downregulated LPS-induced levels of FAK phosphorylation, suggesting that ALWPs modulate FAK signaling to alter LPS-induced IL-1β levels. In addition, treatment with ALWPs followed by LPS resulted in decreased levels of the transcription factor NF-κB in the nucleus compared with LPS alone. Moreover, ALWPs significantly suppressed LPS-induced BV2 microglial cell migration. To examine whether ALWPs modulate learning and memory in vivo, wild-type C57BL/6J mice were orally administered ALWPs (200 mg/kg) or PBS daily for 3 days, intraperitoneally injected (i.p.) with LPS (250 μg/kg) or PBS, and assessed in Y maze and NOR tests. We observed that oral administration of ALWPs to LPS-injected wild-type C57BL/6J mice significantly rescued short- and long-term memory. More importantly, oral administration of ALWPs to LPS-injected wild-type C57BL/6J mice significantly reduced microglial activation in the hippocampus and cortex. Taken together, our results suggest that ALWPs can suppress neuroinflammation-associated cognitive deficits and that ALWPs have potential as a drug for neuroinflammation/neurodegeneration-related diseases, including Alzheimer's disease (AD)." @default.
• W2893614816 created "2018-10-05" @default.
• W2893614816 creator A5004238629 @default.
• W2893614816 creator A5004810455 @default.
• W2893614816 creator A5010769829 @default.
• W2893614816 creator A5012493706 @default.
• W2893614816 creator A5022447937 @default.
• W2893614816 creator A5024408571 @default.
• W2893614816 creator A5029558974 @default.
• W2893614816 creator A5032336228 @default.
• W2893614816 creator A5075676556 @default.
• W2893614816 creator A5075991846 @default.
• W2893614816 creator A5079808024 @default.
• W2893614816 creator A5085357548 @default.
• W2893614816 creator A5089235670 @default.
• W2893614816 creator A5090402987 @default.
• W2893614816 date "2018-09-26" @default.
• W2893614816 modified "2023-09-29" @default.
• W2893614816 title "An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways" @default.
• W2893614816 cites W1520632460 @default.
• W2893614816 cites W1521031916 @default.
• W2893614816 cites W1540228912 @default.
• W2893614816 cites W1857824984 @default.
• W2893614816 cites W1904705252 @default.
• W2893614816 cites W1915977580 @default.
• W2893614816 cites W1963894366 @default.
• W2893614816 cites W1965242506 @default.
• W2893614816 cites W1975758493 @default.
• W2893614816 cites W1976630082 @default.
• W2893614816 cites W1985553766 @default.
• W2893614816 cites W1992686988 @default.
• W2893614816 cites W1992808792 @default.
• W2893614816 cites W1996024251 @default.
• W2893614816 cites W1998446258 @default.
• W2893614816 cites W1999141845 @default.
• W2893614816 cites W2000354382 @default.
• W2893614816 cites W2003674452 @default.
• W2893614816 cites W2005333160 @default.
• W2893614816 cites W2012543041 @default.
• W2893614816 cites W2013237027 @default.
• W2893614816 cites W2015186493 @default.
• W2893614816 cites W2017643504 @default.
• W2893614816 cites W2018607958 @default.
• W2893614816 cites W2026193456 @default.
• W2893614816 cites W2027338872 @default.
• W2893614816 cites W2027347404 @default.
• W2893614816 cites W2030174218 @default.
• W2893614816 cites W2040290877 @default.
• W2893614816 cites W2045786330 @default.
• W2893614816 cites W2047936696 @default.
• W2893614816 cites W2051493532 @default.
• W2893614816 cites W2058729892 @default.
• W2893614816 cites W2059996790 @default.
• W2893614816 cites W2061434349 @default.
• W2893614816 cites W2067267561 @default.
• W2893614816 cites W2067680656 @default.
• W2893614816 cites W2074367636 @default.
• W2893614816 cites W2076800034 @default.
• W2893614816 cites W2083084069 @default.
• W2893614816 cites W2083799472 @default.
• W2893614816 cites W2086469696 @default.
• W2893614816 cites W2087243986 @default.
• W2893614816 cites W2093100587 @default.
• W2893614816 cites W2095085207 @default.
• W2893614816 cites W2099157718 @default.
• W2893614816 cites W2106492904 @default.
• W2893614816 cites W2106673507 @default.
• W2893614816 cites W2107997122 @default.
• W2893614816 cites W2109060944 @default.
• W2893614816 cites W2109235361 @default.
• W2893614816 cites W2109759840 @default.
• W2893614816 cites W2110777046 @default.
• W2893614816 cites W2114395128 @default.
• W2893614816 cites W2119958966 @default.
• W2893614816 cites W2119969939 @default.
• W2893614816 cites W2122044177 @default.
• W2893614816 cites W2128328936 @default.
• W2893614816 cites W2131607023 @default.
• W2893614816 cites W2131665068 @default.
• W2893614816 cites W2132259121 @default.
• W2893614816 cites W2135919238 @default.
• W2893614816 cites W2137829901 @default.
• W2893614816 cites W2154663804 @default.
• W2893614816 cites W2165463936 @default.
• W2893614816 cites W2167276152 @default.
• W2893614816 cites W2170644095 @default.
• W2893614816 cites W2190404250 @default.
• W2893614816 cites W2205544783 @default.
• W2893614816 cites W2230590769 @default.
• W2893614816 cites W2233667077 @default.
• W2893614816 cites W2255840627 @default.
• W2893614816 cites W2268091251 @default.
• W2893614816 cites W2292907345 @default.
• W2893614816 cites W2337118882 @default.
• W2893614816 cites W2346086278 @default.
• W2893614816 cites W2374967976 @default.
• W2893614816 cites W2426168356 @default.
• W2893614816 cites W2475914740 @default.
• W2893614816 cites W2531949738 @default.
• W2893614816 cites W2570251421 @default.

• next