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- W2893622272 abstract "Background . Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations. Objective . To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district. Design and methods . We present the results of the pharmacoepidemiological study of the regional pharmaceutical market of the antihypertensive fixeddoses combinations in Khabarovskii, Primorskii region and the Sakhalin region in 2015–2017. Results . In the studied regions of the Russian Federation, combinations of angiotensin-converting-enzyme inhibitors and diuretics are the most popular. Leading ones appeared to be enalapril + hydrochlorothiazide and perindopril + indapamide. Combinations of angiotensin-converting-enzyme inhibitors with dihydropyridine derivatives calcium channel blockers were acquired seldom. The most popular combinations were perindopril + amlodipine and lizinopril + amlodipine. Among combinations of angiotensin II antagonists with diuretics losartan + hydrochlorothiazide and valsartan + hydrochlorothiazide showed the greatest sales. Combinations including sartan and calcium channel blockers were acquired more seldom, despite the wide range of international non-proprietary variants in drugstores. Atenolol + chlortalidone was in the most popular demand among combinations of β-blockers with diuretics. In 2016 three-component combinations were presented by only four trade names, and their demand is still limited. Nevertheless, a nonsignificant growth of purchases was observed. Conclusions . Our data show low demand of fixed-doses combinations. In regions, as a rule, there is an increase in sales of generic more affordable combinations which proves the significance of both antihypertensive efficiency and the price." @default.
- W2893622272 created "2018-10-05" @default.
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- W2893622272 date "2018-09-26" @default.
- W2893622272 modified "2023-09-23" @default.
- W2893622272 title "Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the far Eastern federal district" @default.
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- W2893622272 doi "https://doi.org/10.18705/1607-419x-2018-24-4-469-477" @default.
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