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• W2893622300 abstract "Selection of specific tumor antigens for cancer therapy remains a major challenge. Glypicans are expressed in cancers and embryonic tissues during development; however, their expression is strictly suppressed in most adult normal tissues, which makes glypicans attractive tumor-specific antigens. The most significant structural characteristic of glypicans is their various numbers of heparan sulfate chains close to the cell membrane. This unique structure endows glypicans with the ability to rescue and sequester various growth factors, morphogens, chemokines, and cytokines under physiological conditions. In this sense, glypicans act as essential coreceptors and trigger the activation of Wnt, Hh, FGF, and many other signaling pathways. Unlike conventional full-size antibodies, single-domain antibodies can bind to cavities on antigens (e.g., the buried active sites of enzymes). Together with other advantages including their small size, thermal stability, and good tissue penetration, single-domain antibodies may become a new direction for next-generation antibody-based therapies. Glypican-targeted antibody-based therapies, including vaccines, immunotoxins, bispecific antibodies, and engineered T cell therapy, are being intensively investigated in many preclinical and clinical studies. Efforts are now aimed at overcoming the immunosuppressive microenvironment and improving T cell infiltration and persistence by developing new strategies and combinations of existing therapies. Glypicans are a group of cell-surface glycoproteins in which heparan sulfate (HS) glycosaminoglycan chains are covalently linked to a protein core. The glypican gene family is broadly conserved across animal species and plays important roles in biological processes. Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively. Antibody-based therapies targeting glypicans are being investigated in preclinical and clinical studies, with the goal of treating solid tumors that do not respond to standard therapies. These studies may establish glypicans as a new class of therapeutic targets for treating cancer. Glypicans are a group of cell-surface glycoproteins in which heparan sulfate (HS) glycosaminoglycan chains are covalently linked to a protein core. The glypican gene family is broadly conserved across animal species and plays important roles in biological processes. Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively. Antibody-based therapies targeting glypicans are being investigated in preclinical and clinical studies, with the goal of treating solid tumors that do not respond to standard therapies. These studies may establish glypicans as a new class of therapeutic targets for treating cancer." @default.
• W2893622300 created "2018-10-05" @default.
• W2893622300 creator A5015105154 @default.
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• W2893622300 creator A5036658104 @default.
• W2893622300 creator A5078088147 @default.
• W2893622300 date "2018-11-01" @default.
• W2893622300 modified "2023-10-14" @default.
• W2893622300 title "Glypicans as Cancer Therapeutic Targets" @default.
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