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- W2893625926 abstract "AIM AND OBJECTIVES: The present investigation was aimed to screen the anti-diabetic activity ofMallotus Philippensis Muell.Arg. on sterptozotocin induced diabetic Wistar albinorats. The objective of the present study to:Find out the phytochemical constituents present in the ethanolic extract of thewhole plant of Mallotus Philippensis Muell.Arg.Acute toxicity studiesEvaluation of anti-diabetic activityBlood glucose level, Glycosylated haemoglobin, Estimation of Serum parameters Total cholesterol levelSerum aspartate amino transferace level (AST)Serum alanine amino transferace level (ALT)Estimation of Oxidative stress parametersLiver malondialdehyde level (MDA)Estimation of enzymic hepatic antioxidant parametersLiver superoxide dismutase level (SOD)Liver catalase level (CAT)Liver glutathione peroxide level (GPx)Estimation of non-enzymic anti-oxidant activityReduced glutathione (GSH) levelAscorbic acid (Vitamin C) levelα –tocopherol (Vitamin E) levelEstimation of plasma insulin levelHistopathology of pancreas.Statistical analysis SUMMARY AND CONCLUSION: The present study was undertaken to scientifically elucidate the anti-diabeticactivity of alcoholic fruit extract of Mallotus Phililppensis Muell.Arg.The phytochemical investigation revealed the presence of carbohydrates,steroids, phenols, tannins, flavanoids, glycosides, and terpenes in the EEMP.The STZ 45 mg/kg effectively induced diabetes, which was similar to diabetes inhuman. Therefore it is an effective and an ideal model for diabetes research.The Blood glucose level and Glycosylated haemoglobin level significantlydecreased with treatment of EEMP proves it having anti-diabetic activity.Attenuating the increased serum parameters like total cholesterol, AST and ALTwith treatment of EEMP showed its anti-diabetic activity.Reduced level of lipid peroxidation in EEMP treated rats, showed EEMP hasprotective effect in oxidative stress induced diabetes.The enzymic antioxidant parameters such as SOD, CAT and GPx andNon-enzymic antioxidant parameters such as GSH, Vitamin C and Vitamin E areincreased significantly with treatment of EEMP, which proved as it having antioxidantactivity.The plasma insulin level significantly increased with treatment of EEMP, showedthe EEMP in managing hyperglycemia and diabetic complications.Mallotus Phililppensis Muell.Arg.fruit extract also have favourable effects toinhibit the histopathological change of the pancreas in STZ induced diabetes.In summary, alcoholic fruit extract of Mallotus Phililppensis Muell.Arg showedstatistically significant anti-diabetic activity.In conclusion, the alcoholic fruit extract of Mallotus Phililppensis Muell.Arg.showed and offered a promising therapeutic value in prevention of diabetes. Theseeffects was mainly attributed to its antioxidant properties by significant quenching impact of the extract on lipid peroxidation along with enhancement of enzymatic andnon-enzymatic antioxidant defense systems in liver and pancreatic tissue.Further studies will be needed in future to determine the exact phytoconstituentsin the extract, which having anti-diabetic activity." @default.
- W2893625926 created "2018-10-05" @default.
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- W2893625926 date "2016-10-01" @default.
- W2893625926 modified "2023-09-27" @default.
- W2893625926 title "Antidiabetic Activity of Alcoholic Fruit Extract of Mallotus Philippensis Muell.Arg. in Streptozotocin Induced Dibetic Rats" @default.
- W2893625926 hasPublicationYear "2016" @default.
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