Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893629488> ?p ?o ?g. }
- W2893629488 endingPage "74" @default.
- W2893629488 startingPage "65" @default.
- W2893629488 abstract "Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipulated to form insulin-producing cells. This review will present an overview of recent reports that demonstrate the potential of utilizing pancreatic ductal cells (PDCs) for reprogramming into insulin- producing cells, focusing on the recent advances and the conflicting views. A large pool of ductal cells is released along with islets during the human islet isolation process, but these cells are separated from the pure islets during the purification process. By identifying and improving existing ductal cell culture methods and developing a better understanding of mechanisms by which these cells can be manipulated to form hormone-producing islet-like cells, PDCs could prove to be a strong clinical tool in providing an alternative beta cell source, thus helping CP patients maintain their long-term glucose levels." @default.
- W2893629488 created "2018-10-05" @default.
- W2893629488 creator A5001583352 @default.
- W2893629488 creator A5007431205 @default.
- W2893629488 creator A5009856948 @default.
- W2893629488 creator A5018067437 @default.
- W2893629488 creator A5026387210 @default.
- W2893629488 creator A5036426378 @default.
- W2893629488 creator A5072419465 @default.
- W2893629488 creator A5089664464 @default.
- W2893629488 creator A5090507736 @default.
- W2893629488 date "2019-01-14" @default.
- W2893629488 modified "2023-09-29" @default.
- W2893629488 title "Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis" @default.
- W2893629488 cites W1655026638 @default.
- W2893629488 cites W1832527205 @default.
- W2893629488 cites W1838707203 @default.
- W2893629488 cites W1891286077 @default.
- W2893629488 cites W1959950910 @default.
- W2893629488 cites W1964497742 @default.
- W2893629488 cites W1964847767 @default.
- W2893629488 cites W1973752547 @default.
- W2893629488 cites W1977527932 @default.
- W2893629488 cites W1978653015 @default.
- W2893629488 cites W1981362835 @default.
- W2893629488 cites W1990826732 @default.
- W2893629488 cites W1998119817 @default.
- W2893629488 cites W1999179141 @default.
- W2893629488 cites W2003051170 @default.
- W2893629488 cites W2004934060 @default.
- W2893629488 cites W2006475805 @default.
- W2893629488 cites W2011710385 @default.
- W2893629488 cites W2015457818 @default.
- W2893629488 cites W2017524098 @default.
- W2893629488 cites W2020811156 @default.
- W2893629488 cites W2026748222 @default.
- W2893629488 cites W2026925157 @default.
- W2893629488 cites W2032203942 @default.
- W2893629488 cites W2034855296 @default.
- W2893629488 cites W2036085625 @default.
- W2893629488 cites W2037029587 @default.
- W2893629488 cites W2054050767 @default.
- W2893629488 cites W2054064865 @default.
- W2893629488 cites W2055793131 @default.
- W2893629488 cites W2055843287 @default.
- W2893629488 cites W2057361172 @default.
- W2893629488 cites W2061980853 @default.
- W2893629488 cites W2065459869 @default.
- W2893629488 cites W2074899704 @default.
- W2893629488 cites W2076323074 @default.
- W2893629488 cites W2081610020 @default.
- W2893629488 cites W2084089742 @default.
- W2893629488 cites W2089688272 @default.
- W2893629488 cites W2098511833 @default.
- W2893629488 cites W2098812327 @default.
- W2893629488 cites W2103142112 @default.
- W2893629488 cites W2105031631 @default.
- W2893629488 cites W2107890914 @default.
- W2893629488 cites W2110509725 @default.
- W2893629488 cites W2113591270 @default.
- W2893629488 cites W2114058685 @default.
- W2893629488 cites W2115259598 @default.
- W2893629488 cites W2117391590 @default.
- W2893629488 cites W2119578188 @default.
- W2893629488 cites W2126491715 @default.
- W2893629488 cites W2126780067 @default.
- W2893629488 cites W2128934917 @default.
- W2893629488 cites W2131560138 @default.
- W2893629488 cites W2131932336 @default.
- W2893629488 cites W2132289617 @default.
- W2893629488 cites W2146383332 @default.
- W2893629488 cites W2150555703 @default.
- W2893629488 cites W2153123634 @default.
- W2893629488 cites W2154532011 @default.
- W2893629488 cites W2164215069 @default.
- W2893629488 cites W2164998851 @default.
- W2893629488 cites W2165796220 @default.
- W2893629488 cites W2169337437 @default.
- W2893629488 cites W2169803834 @default.
- W2893629488 cites W2176095569 @default.
- W2893629488 cites W2227703011 @default.
- W2893629488 cites W2249498033 @default.
- W2893629488 cites W2323566388 @default.
- W2893629488 cites W2328786770 @default.
- W2893629488 cites W2341414956 @default.
- W2893629488 cites W2414175118 @default.
- W2893629488 cites W2414782824 @default.
- W2893629488 cites W2469085947 @default.
- W2893629488 cites W2474710707 @default.
- W2893629488 cites W2508786792 @default.
- W2893629488 cites W2516382154 @default.
- W2893629488 cites W2523369352 @default.
- W2893629488 cites W2523419694 @default.
- W2893629488 cites W2523620612 @default.
- W2893629488 cites W2539044895 @default.
- W2893629488 cites W2550450177 @default.
- W2893629488 cites W2617618077 @default.
- W2893629488 cites W2624613262 @default.