FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893629903> ?p ?o ?g. }

• W2893629903 endingPage "243" @default.
• W2893629903 startingPage "235" @default.
• W2893629903 abstract "Patients with Lynch syndrome have up to a 24% risk of developing ovarian carcinoma, but universal mismatch repair (MMR) protein testing of ovarian carcinomas is not standard practice in most institutions. We reviewed 104 unselected ovarian endometrioid carcinomas (OEC) for various clinicopathologic features to determine if any are predictive of MMR loss. Immunohistochemistry for all 4 MMR proteins was performed followed by MLH1 promoter methylation analysis when indicated. Overall, patients had a mean age of 55 years and tumors averaged 12 cm. Most (72%) patients had stage I tumors, 63% were grade 1, and 30% had a synchronous stage IA endometrial endometrioid carcinoma. Peritumoral lymphocytes and intratumoral stromal inflammation were rare, but tumor-infiltrating lymphocytes averaged 47/10 high-power fields. Endometriosis was noted in 71%, adenofibromatous background in 14%, and both in 14% of tumors. Metaplastic changes were common and included squamous metaplasia (63%), clear cell change (32%), mucinous differentiation (24%), and sex cord-like elements (13%). When follow-up was available (n=99), 78% of patients were alive and well, 12% died from disease, 6% died from other causes, and 4% were alive with disease. Unmethylated, MMR-deficient OECs were identified in 7% of the cohort and included MSH2/MSH6 (n=4), MSH6 (n=2), and PMS2 (n=1). All these tumors were stage I, 71% grade 1, and 57% had a synchronous endometrial endometrioid carcinoma. Among patients in this group with follow-up (n=5), all were alive without evidence of disease (mean 150 mo). Given that no clinicopathologic features were associated with MMR deficiency on univariate analysis, this study highlights the importance of universal MMR screening in OECs." @default.
• W2893629903 created "2018-10-05" @default.
• W2893629903 creator A5016164818 @default.
• W2893629903 creator A5025407530 @default.
• W2893629903 creator A5041300253 @default.
• W2893629903 creator A5052359409 @default.
• W2893629903 creator A5078592778 @default.
• W2893629903 creator A5086787481 @default.
• W2893629903 date "2019-02-01" @default.
• W2893629903 modified "2023-10-17" @default.
• W2893629903 title "Incidence of Mismatch Repair Protein Deficiency and Associated Clinicopathologic Features in a Cohort of 104 Ovarian Endometrioid Carcinomas" @default.
• W2893629903 cites W1993556476 @default.
• W2893629903 cites W1995689336 @default.
• W2893629903 cites W2003394553 @default.
• W2893629903 cites W2004036465 @default.
• W2893629903 cites W2018020434 @default.
• W2893629903 cites W2026955611 @default.
• W2893629903 cites W2060710557 @default.
• W2893629903 cites W2060940764 @default.
• W2893629903 cites W2067182044 @default.
• W2893629903 cites W2072891853 @default.
• W2893629903 cites W2091017768 @default.
• W2893629903 cites W2095613768 @default.
• W2893629903 cites W2159899668 @default.
• W2893629903 cites W2165092254 @default.
• W2893629903 cites W2233016591 @default.
• W2893629903 cites W2258945793 @default.
• W2893629903 cites W2264060967 @default.
• W2893629903 cites W2270264837 @default.
• W2893629903 cites W2314787270 @default.
• W2893629903 cites W2315998729 @default.
• W2893629903 cites W2337786508 @default.
• W2893629903 cites W2416692452 @default.
• W2893629903 cites W2461049658 @default.
• W2893629903 cites W2514714642 @default.
• W2893629903 cites W2568126178 @default.
• W2893629903 cites W2587556669 @default.
• W2893629903 cites W2744601229 @default.
• W2893629903 cites W2767122961 @default.
• W2893629903 cites W2775367434 @default.
• W2893629903 cites W2798047324 @default.
• W2893629903 cites W2800573905 @default.
• W2893629903 doi "https://doi.org/10.1097/pas.0000000000001165" @default.
• W2893629903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256257" @default.
• W2893629903 hasPublicationYear "2019" @default.
• W2893629903 type Work @default.
• W2893629903 sameAs 2893629903 @default.
• W2893629903 citedByCount "27" @default.
• W2893629903 countsByYear W28936299032019 @default.
• W2893629903 countsByYear W28936299032020 @default.
• W2893629903 countsByYear W28936299032021 @default.
• W2893629903 countsByYear W28936299032022 @default.
• W2893629903 countsByYear W28936299032023 @default.
• W2893629903 crossrefType "journal-article" @default.
• W2893629903 hasAuthorship W2893629903A5016164818 @default.
• W2893629903 hasAuthorship W2893629903A5025407530 @default.
• W2893629903 hasAuthorship W2893629903A5041300253 @default.
• W2893629903 hasAuthorship W2893629903A5052359409 @default.
• W2893629903 hasAuthorship W2893629903A5078592778 @default.
• W2893629903 hasAuthorship W2893629903A5086787481 @default.
• W2893629903 hasConcept C111425858 @default.
• W2893629903 hasConcept C121608353 @default.
• W2893629903 hasConcept C126322002 @default.
• W2893629903 hasConcept C142724271 @default.
• W2893629903 hasConcept C143998085 @default.
• W2893629903 hasConcept C2776559941 @default.
• W2893629903 hasConcept C2776674815 @default.
• W2893629903 hasConcept C2777546739 @default.
• W2893629903 hasConcept C2778677574 @default.
• W2893629903 hasConcept C2779115348 @default.
• W2893629903 hasConcept C526805850 @default.
• W2893629903 hasConcept C60748783 @default.
• W2893629903 hasConcept C71924100 @default.
• W2893629903 hasConcept C72563966 @default.
• W2893629903 hasConcept C90924648 @default.
• W2893629903 hasConceptScore W2893629903C111425858 @default.
• W2893629903 hasConceptScore W2893629903C121608353 @default.
• W2893629903 hasConceptScore W2893629903C126322002 @default.
• W2893629903 hasConceptScore W2893629903C142724271 @default.
• W2893629903 hasConceptScore W2893629903C143998085 @default.
• W2893629903 hasConceptScore W2893629903C2776559941 @default.
• W2893629903 hasConceptScore W2893629903C2776674815 @default.
• W2893629903 hasConceptScore W2893629903C2777546739 @default.
• W2893629903 hasConceptScore W2893629903C2778677574 @default.
• W2893629903 hasConceptScore W2893629903C2779115348 @default.
• W2893629903 hasConceptScore W2893629903C526805850 @default.
• W2893629903 hasConceptScore W2893629903C60748783 @default.
• W2893629903 hasConceptScore W2893629903C71924100 @default.
• W2893629903 hasConceptScore W2893629903C72563966 @default.
• W2893629903 hasConceptScore W2893629903C90924648 @default.
• W2893629903 hasIssue "2" @default.
• W2893629903 hasLocation W28936299031 @default.
• W2893629903 hasLocation W28936299032 @default.
• W2893629903 hasOpenAccess W2893629903 @default.
• W2893629903 hasPrimaryLocation W28936299031 @default.
• W2893629903 hasRelatedWork W1985184859 @default.
• W2893629903 hasRelatedWork W2089843864 @default.
• W2893629903 hasRelatedWork W2093026817 @default.

• next