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- W2893631054 abstract "The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) and cardiotrophin-like cytokine factor 1 (CLCF1). Membership of this cytokine family is defined by usage of common β-receptor signalling subunits, which activate various intracellular signalling pathways. Each IL-6 family member elicits responses essential to the physiological control of immune homeostasis, haematopoiesis, inflammation, development and metabolism. Accordingly, distortion of these cytokine activities often promotes chronic disease and cancer; the pathological importance of this is exemplified by the successful treatment of certain autoimmune conditions with drugs that target the IL-6 pathway. Here, we discuss the emerging roles for IL-6 family members in infection, chronic inflammation, autoimmunity and cancer and review therapeutic strategies designed to manipulate these cytokines in disease. This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer." @default.
- W2893631054 created "2018-10-05" @default.
- W2893631054 creator A5032199136 @default.
- W2893631054 creator A5055490340 @default.
- W2893631054 date "2018-09-25" @default.
- W2893631054 modified "2023-10-10" @default.
- W2893631054 title "Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer" @default.
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