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- W2893631393 abstract "Abstract MicroRNAs (miRNAs) are small noncoding RNAs composed of 19–25 nucleotides. During pregnancy, miRNAs are extensively expressed in the placenta. They are not only involved in regulating multiple cell event at the fetomaternal interface, but are also released into maternal blood to modulate maternal pregnancy adaptation. The fine-tune regulation of pregnancy by miRNAs adds a new dimension for pregnant physiology and pathology. In this chapter, we will briefly introduce the pregnancy-related miRNAs, including placenta-derived miRNAs, placenta-specific miRNAs, and the differentially expressed miRNAs in pregnancy complications. The functions of these miRNAs are in association with embryonic implantation, placentation, maternal-fetal immunoadaptation, and long-term fetal health. The miRNAs that are released into the maternal blood may reflect the status of the fetomaternal interface and exhibit as potential biomarkers for pregnancy outcomes. In-depth investigation on miRNAs provides valuable information to further our understanding of the physiological and pathological mechanisms in pregnancy." @default.
- W2893631393 created "2018-10-05" @default.
- W2893631393 creator A5018010593 @default.
- W2893631393 creator A5047604705 @default.
- W2893631393 creator A5057820341 @default.
- W2893631393 creator A5080102032 @default.
- W2893631393 date "2019-01-01" @default.
- W2893631393 modified "2023-09-26" @default.
- W2893631393 title "microRNAs in Pregnancy: Implications for Basic Research and Clinical Management" @default.
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