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• W2893633465 abstract "Amyloid β (Aβ) peptide accumulation in the brain is considered to be one of the hallmarks of Alzheimer's disease. Here, we compare two analytical techniques for detecting neurotoxic Aβ1-42 oligomers - Quartz Crystal Microbalance with Dissipation (QCM-D) and Single Molecule Array (Simoa). Both detection methods exploit a feature of the monoclonal antibody bapineuzumab, which targets N-terminal residues 1–5 of Aβ with high affinity and use it as both a capture and detection reagent. Assays developed with the two methods allow us to specifically recognize neurotoxic Aβ1-42 oligomers and higher aggregates such as fibrils but discriminate against Aβ1-42 monomer species. We find that for detection of Aβ1-42 oligomers, Simoa was roughly 500 times more sensitive than the QCM-D technique with limits of detection of 0.22 nM and 125 nM, respectively." @default.
• W2893633465 created "2018-10-05" @default.
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• W2893633465 date "2019-02-01" @default.
• W2893633465 modified "2023-10-10" @default.
• W2893633465 title "Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease" @default.
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• W2893633465 doi "https://doi.org/10.1016/j.ab.2018.09.011" @default.
• W2893633465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267709" @default.
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