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• W2893635239 abstract "Abstract Post-transcriptional regulation of gene expression plays an essential role during oocyte maturation. Here we report that Drosophila MARF1 (Meiosis Regulator And mRNA Stability Factor 1), which consists of one RNA-recognition motif and six tandem LOTUS domains with unknown molecular function, is essential for oocyte maturation. When tethered to a reporter mRNA, MARF1 post-transcriptionally silences reporter expression by shortening reporter mRNA poly-A tail length and thereby reducing reporter protein level. This activity is mediated by the MARF1 LOTUS domain, which binds the CCR4-NOT deadenylase complex. MARF1 binds cyclin A mRNA and shortens its poly-A tail to reduce Cyclin A protein level during oocyte maturation. This study identifies MARF1 as a regulator in oocyte maturation and defines the conserved LOTUS domain as a post-transcriptional effector domain that recruits CCR4-NOT deadenylase complex to shorten target mRNA poly-A tails and suppress their translation." @default.
• W2893635239 created "2018-10-05" @default.
• W2893635239 creator A5012343940 @default.
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• W2893635239 creator A5047571831 @default.
• W2893635239 date "2018-10-02" @default.
• W2893635239 modified "2023-10-12" @default.
• W2893635239 title "LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes" @default.
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• W2893635239 doi "https://doi.org/10.1038/s41467-018-06404-w" @default.
• W2893635239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168497" @default.
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• W2893635239 hasPublicationYear "2018" @default.
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