Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893636620> ?p ?o ?g. }
- W2893636620 endingPage "1626" @default.
- W2893636620 startingPage "1609" @default.
- W2893636620 abstract "Group 2 innate lymphoid cells (ILC2s) are derived from common lymphoid progenitors (CLPs) via several specific precursors, and the transcription factors essential for ILC2 differentiation have been extensively studied. However, the external factors regulating commitment to the ILC lineage as well as the sites and stromal cells that constitute the optimal microenvironment for ILC2-specific differentiation are not fully defined. In this study, we demonstrate that three key external factors, the concentration of interleukin 7 (IL-7) and strength and duration of Notch signaling, coordinately determine the fate of CLP toward the T, B, or ILC lineage. Additionally, we identified three stages of ILC2 in the fetal mesentery that require STAT5 signals for maturation: ILC progenitors, CCR9+ ILC2 progenitors, and KLRG1- immature ILC2. We further demonstrate that ILC2 development is supported by mesenteric platelet-derived growth factor receptor α (PDGFRα)+ glycoprotein 38 (gp38)+ mesenchymal cells. Collectively, our results suggest that early differentiation of ILC2 occurs in the fetal liver via IL-7 and Notch signaling, whereas final differentiation occurs in the periphery with the aid of PDGFRα+gp38+ cells." @default.
- W2893636620 created "2018-10-05" @default.
- W2893636620 creator A5003440749 @default.
- W2893636620 creator A5010453285 @default.
- W2893636620 creator A5035309136 @default.
- W2893636620 creator A5042992485 @default.
- W2893636620 creator A5062421095 @default.
- W2893636620 creator A5074899808 @default.
- W2893636620 creator A5084178900 @default.
- W2893636620 creator A5091330956 @default.
- W2893636620 date "2018-05-04" @default.
- W2893636620 modified "2023-10-17" @default.
- W2893636620 title "Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver–derived ILC2" @default.
- W2893636620 cites W109230952 @default.
- W2893636620 cites W1164981660 @default.
- W2893636620 cites W1547920084 @default.
- W2893636620 cites W1579580886 @default.
- W2893636620 cites W1889701339 @default.
- W2893636620 cites W1944461161 @default.
- W2893636620 cites W1950049307 @default.
- W2893636620 cites W1964934170 @default.
- W2893636620 cites W1965774491 @default.
- W2893636620 cites W1970428748 @default.
- W2893636620 cites W1976073214 @default.
- W2893636620 cites W1985732675 @default.
- W2893636620 cites W1993500521 @default.
- W2893636620 cites W1994569436 @default.
- W2893636620 cites W1994875855 @default.
- W2893636620 cites W1995171688 @default.
- W2893636620 cites W1996893147 @default.
- W2893636620 cites W1997745506 @default.
- W2893636620 cites W2006538571 @default.
- W2893636620 cites W2007923700 @default.
- W2893636620 cites W2014782531 @default.
- W2893636620 cites W2015234837 @default.
- W2893636620 cites W2022969625 @default.
- W2893636620 cites W2024183493 @default.
- W2893636620 cites W2026243235 @default.
- W2893636620 cites W2033289727 @default.
- W2893636620 cites W2043692591 @default.
- W2893636620 cites W2046271789 @default.
- W2893636620 cites W2046928493 @default.
- W2893636620 cites W2047882259 @default.
- W2893636620 cites W2052306889 @default.
- W2893636620 cites W2062618476 @default.
- W2893636620 cites W2064433193 @default.
- W2893636620 cites W2069089843 @default.
- W2893636620 cites W2073516129 @default.
- W2893636620 cites W2078498449 @default.
- W2893636620 cites W2081769332 @default.
- W2893636620 cites W2086121828 @default.
- W2893636620 cites W2090033479 @default.
- W2893636620 cites W2100379729 @default.
- W2893636620 cites W2102139611 @default.
- W2893636620 cites W2102212449 @default.
- W2893636620 cites W2103572248 @default.
- W2893636620 cites W2107023210 @default.
- W2893636620 cites W2119080021 @default.
- W2893636620 cites W2120908143 @default.
- W2893636620 cites W2131777330 @default.
- W2893636620 cites W2147507075 @default.
- W2893636620 cites W2149557024 @default.
- W2893636620 cites W2152893906 @default.
- W2893636620 cites W2155358087 @default.
- W2893636620 cites W2155696890 @default.
- W2893636620 cites W2166535431 @default.
- W2893636620 cites W2182536415 @default.
- W2893636620 cites W2253694685 @default.
- W2893636620 cites W2259244976 @default.
- W2893636620 cites W2266367473 @default.
- W2893636620 cites W2301038687 @default.
- W2893636620 cites W2466489636 @default.
- W2893636620 cites W2513111034 @default.
- W2893636620 cites W2518245007 @default.
- W2893636620 cites W2592526947 @default.
- W2893636620 cites W2615441390 @default.
- W2893636620 cites W2727087240 @default.
- W2893636620 cites W2769255069 @default.
- W2893636620 cites W2773338109 @default.
- W2893636620 doi "https://doi.org/10.1084/jem.20172310" @default.
- W2893636620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5987924" @default.
- W2893636620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29728440" @default.
- W2893636620 hasPublicationYear "2018" @default.
- W2893636620 type Work @default.
- W2893636620 sameAs 2893636620 @default.
- W2893636620 citedByCount "85" @default.
- W2893636620 countsByYear W28936366202018 @default.
- W2893636620 countsByYear W28936366202019 @default.
- W2893636620 countsByYear W28936366202020 @default.
- W2893636620 countsByYear W28936366202021 @default.
- W2893636620 countsByYear W28936366202022 @default.
- W2893636620 countsByYear W28936366202023 @default.
- W2893636620 crossrefType "journal-article" @default.
- W2893636620 hasAuthorship W2893636620A5003440749 @default.
- W2893636620 hasAuthorship W2893636620A5010453285 @default.
- W2893636620 hasAuthorship W2893636620A5035309136 @default.
- W2893636620 hasAuthorship W2893636620A5042992485 @default.
- W2893636620 hasAuthorship W2893636620A5062421095 @default.