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- W2893638732 abstract "Mitogenic lectins, such as Phaseolus vulgaris leucoagglutinin and Concanavalin A, stimulate human peripheral blood lymphocytes to blast transformation and DNA synthesis. The mechanism by which lectins trigger lymphocytes is not known, but an essential first step for activation is the interaction of the carbohydrate binding site of the lectin with the cell surface glycoprotein or glycolipid receptor. The binding of the lectin to these surface membrane components results in a number of biochemical changes such as enhanced membrane fluidity, increased uptake of amino acids and ions, and increased protein- and RNA-synthesis. This chapter describes the study of relationship between bindings of lectins to surface receptors on lymphocytes and the capacity of the lectin to induce DNA synthesis." @default.
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- W2893638732 date "1976-01-01" @default.
- W2893638732 modified "2023-09-26" @default.
- W2893638732 title "INTERACTION OF NON-MITOGENIC AND MITOGENIC LECTINS WITH T LYMPHOCYTES. ASSOCIATION OF CELLULAR RECEPTOR SITES**Supported by Grant no. 2032-047 from the Swedish Natural Science Research Council." @default.
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- W2893638732 doi "https://doi.org/10.1016/b978-0-12-233750-5.50008-7" @default.
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