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• W2893640158 startingPage "1855" @default.
• W2893640158 abstract "Hyperleptinemia has been independently associated with human cardiovascular (CV) diseases. Accordingly, we evaluate the association between serum leptin and future CV events in patients with coronary artery disease (CAD).This study enrolled 98 patients with CAD from January to December 2012. The primary endpoint included incidences of major adverse CV events and hospitalization. Patients follow-up had been completed on June 30, 2017.After a median follow-up of 52 months, 43 CV events had occurred. Patients with CV events had higher systolic blood pressure (P = 0.030), total cholesterol (P = 0.034), C-reactive protein (P = 0.018), and serum leptin levels (P = 0.001) than those without CV events. Kaplan-Meier analysis showed greater cumulative incidences of CV events in the high leptin group (median leptin concentration >6.03 ng/mL) than in the low leptin group (log-rank P = 0.012). Multivariate Cox regression analysis showed that triglyceride (HR: 1.010; 95% CI: 1.001-1.018; P = 0.022) and leptin levels (HR: 1.054; 95% CI: 1.026-1.082; P < 0.001) were independently associated with CV events in patients with CAD.Serum leptin levels could serve as a biomarker for future CV events in patients with CAD." @default.
• W2893640158 created "2018-10-05" @default.
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• W2893640158 creator A5051883753 @default.
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• W2893640158 date "2018-10-01" @default.
• W2893640158 modified "2023-09-25" @default.
• W2893640158 title "Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease" @default.
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• W2893640158 doi "https://doi.org/10.2147/tcrm.s172231" @default.
• W2893640158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171750" @default.
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