FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893640625> ?p ?o ?g. }

• W2893640625 endingPage "105" @default.
• W2893640625 startingPage "97" @default.
• W2893640625 abstract "Background and Aim Caloric restriction (CR) improves insulin sensitivity and is one of the dietetic strategies most commonly used to enlarge life and to prevent aging-induced cardiovascular alterations. The aim of this study was to analyze the possible beneficial effects of caloric restriction (CR) preventing the aging-induced insulin resistance in the heart of male Wistar rats. Methods and results Three experimental groups were used: 3 months old rats (3m), 24 months old rats (24m) and 24 months old rats subjected to 20% CR during their three last months of life (24m-CR). After sacrifice hearts were mounted in a perfusion system (Langendorff) and heart function in basal conditions and in response to accumulative doses of insulin (10−9-10−7 M), in the presence or absence of Wortmannin (10−6 M), was recorded. CR did not attenuate the aging-induced decrease in coronary artery vasodilation in response to insulin administration, but it prevented the aging-induced downregulation of cardiac contractility (dp/dt) through activation of the PI3K/Akt intracellular pathway. Insulin stimulated in a greater extent the PI3K/Akt pathway vs the activation of the MAPK pathway and increased the protein expression of IR, GLUT-4 and eNOS in the hearts of 3m and 24m-CR rats, but not in the hearts of 24m rats. Furthermore, CR prevented the aging induced increase in endothelin-1 protein expression in myocardial tissue. Conclusion In conclusion CR partially improves cardiac insulin sensitivity and prevents the aging induced decrease in myocardial contractility in response to insulin administration through activation of PI3K/Akt pathway." @default.
• W2893640625 created "2018-10-05" @default.
• W2893640625 creator A5018514872 @default.
• W2893640625 creator A5020831514 @default.
• W2893640625 creator A5025278709 @default.
• W2893640625 creator A5025966783 @default.
• W2893640625 creator A5035130849 @default.
• W2893640625 creator A5037719743 @default.
• W2893640625 creator A5049732750 @default.
• W2893640625 creator A5056339747 @default.
• W2893640625 creator A5058400312 @default.
• W2893640625 date "2019-01-01" @default.
• W2893640625 modified "2023-10-14" @default.
• W2893640625 title "Caloric restriction attenuates aging-induced cardiac insulin resistance in male Wistar rats through activation of PI3K/Akt pathway" @default.
• W2893640625 cites W1509722689 @default.
• W2893640625 cites W1968968110 @default.
• W2893640625 cites W1972464510 @default.
• W2893640625 cites W1980403105 @default.
• W2893640625 cites W2001854860 @default.
• W2893640625 cites W2001893247 @default.
• W2893640625 cites W2019668443 @default.
• W2893640625 cites W2024139795 @default.
• W2893640625 cites W2024512520 @default.
• W2893640625 cites W2065885041 @default.
• W2893640625 cites W2070100445 @default.
• W2893640625 cites W2083002612 @default.
• W2893640625 cites W2085152661 @default.
• W2893640625 cites W2097079712 @default.
• W2893640625 cites W2102248399 @default.
• W2893640625 cites W2102751037 @default.
• W2893640625 cites W2108893914 @default.
• W2893640625 cites W2111154780 @default.
• W2893640625 cites W2119302231 @default.
• W2893640625 cites W2122302447 @default.
• W2893640625 cites W2126975956 @default.
• W2893640625 cites W2128389658 @default.
• W2893640625 cites W2130897958 @default.
• W2893640625 cites W2130899158 @default.
• W2893640625 cites W2146447502 @default.
• W2893640625 cites W2150429576 @default.
• W2893640625 cites W2170374490 @default.
• W2893640625 cites W2171035344 @default.
• W2893640625 cites W2322298770 @default.
• W2893640625 doi "https://doi.org/10.1016/j.numecd.2018.09.005" @default.
• W2893640625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30497927" @default.
• W2893640625 hasPublicationYear "2019" @default.
• W2893640625 type Work @default.
• W2893640625 sameAs 2893640625 @default.
• W2893640625 citedByCount "16" @default.
• W2893640625 countsByYear W28936406252019 @default.
• W2893640625 countsByYear W28936406252020 @default.
• W2893640625 countsByYear W28936406252021 @default.
• W2893640625 countsByYear W28936406252022 @default.
• W2893640625 countsByYear W28936406252023 @default.
• W2893640625 crossrefType "journal-article" @default.
• W2893640625 hasAuthorship W2893640625A5018514872 @default.
• W2893640625 hasAuthorship W2893640625A5020831514 @default.
• W2893640625 hasAuthorship W2893640625A5025278709 @default.
• W2893640625 hasAuthorship W2893640625A5025966783 @default.
• W2893640625 hasAuthorship W2893640625A5035130849 @default.
• W2893640625 hasAuthorship W2893640625A5037719743 @default.
• W2893640625 hasAuthorship W2893640625A5049732750 @default.
• W2893640625 hasAuthorship W2893640625A5056339747 @default.
• W2893640625 hasAuthorship W2893640625A5058400312 @default.
• W2893640625 hasConcept C104317684 @default.
• W2893640625 hasConcept C111566952 @default.
• W2893640625 hasConcept C11960822 @default.
• W2893640625 hasConcept C126322002 @default.
• W2893640625 hasConcept C127561419 @default.
• W2893640625 hasConcept C134018914 @default.
• W2893640625 hasConcept C190283241 @default.
• W2893640625 hasConcept C2777391703 @default.
• W2893640625 hasConcept C2778198053 @default.
• W2893640625 hasConcept C2778308172 @default.
• W2893640625 hasConcept C2779306644 @default.
• W2893640625 hasConcept C39133596 @default.
• W2893640625 hasConcept C55493867 @default.
• W2893640625 hasConcept C71924100 @default.
• W2893640625 hasConcept C75217442 @default.
• W2893640625 hasConcept C86554907 @default.
• W2893640625 hasConcept C86803240 @default.
• W2893640625 hasConceptScore W2893640625C104317684 @default.
• W2893640625 hasConceptScore W2893640625C111566952 @default.
• W2893640625 hasConceptScore W2893640625C11960822 @default.
• W2893640625 hasConceptScore W2893640625C126322002 @default.
• W2893640625 hasConceptScore W2893640625C127561419 @default.
• W2893640625 hasConceptScore W2893640625C134018914 @default.
• W2893640625 hasConceptScore W2893640625C190283241 @default.
• W2893640625 hasConceptScore W2893640625C2777391703 @default.
• W2893640625 hasConceptScore W2893640625C2778198053 @default.
• W2893640625 hasConceptScore W2893640625C2778308172 @default.
• W2893640625 hasConceptScore W2893640625C2779306644 @default.
• W2893640625 hasConceptScore W2893640625C39133596 @default.
• W2893640625 hasConceptScore W2893640625C55493867 @default.
• W2893640625 hasConceptScore W2893640625C71924100 @default.
• W2893640625 hasConceptScore W2893640625C75217442 @default.
• W2893640625 hasConceptScore W2893640625C86554907 @default.
• W2893640625 hasConceptScore W2893640625C86803240 @default.

• next