Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893641676> ?p ?o ?g. }
- W2893641676 abstract "ABSTRACT The nervous system confronts challenges during development and experience that can destabilize information processing. To adapt to these perturbations, synapses homeostatically adjust synaptic strength, a process referred to as homeostatic synaptic plasticity. At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors activates retrograde signaling that precisely increases presynaptic neurotransmitter release to restore baseline synaptic strength. However, the nature of the underlying postsynaptic induction process remains enigmatic. Here, we designed a forward genetic screen to identify factors necessary in the postsynaptic compartment to generate retrograde homeostatic signaling. This approach identified insomniac ( inc ), a gene that encodes a putative adaptor for the Cullin-3 ubiquitin ligase complex and is essential for normal sleep regulation. Intriguingly, we find that Inc rapidly traffics to postsynaptic densities and is required for increased ubiquitination following acute receptor inhibition. Our study suggests that Inc-dependent ubiquitination, compartmentalized at postsynaptic densities, gates retrograde signaling and provides an intriguing molecular link between the control of sleep behavior and homeostatic plasticity at synapses." @default.
- W2893641676 created "2018-10-05" @default.
- W2893641676 creator A5001729142 @default.
- W2893641676 creator A5011941338 @default.
- W2893641676 creator A5014800269 @default.
- W2893641676 creator A5048869064 @default.
- W2893641676 creator A5070144887 @default.
- W2893641676 creator A5074929175 @default.
- W2893641676 creator A5076965328 @default.
- W2893641676 creator A5082698806 @default.
- W2893641676 creator A5088115912 @default.
- W2893641676 date "2018-09-29" @default.
- W2893641676 modified "2023-09-26" @default.
- W2893641676 title "The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling" @default.
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