FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893645079> ?p ?o ?g. }

• W2893645079 endingPage "e0006824" @default.
• W2893645079 startingPage "e0006824" @default.
• W2893645079 abstract "Current Global Program to Eliminate Lymphatic Filariasis (GPELF) that prohibits pregnant mothers and children below two years of age from coverage targeted interruption of transmission after 5-6 rounds of annual mass drug administration (MDA). However, after more than 10 rounds of MDA in India the target has not been achieved, which poses challenge to the researchers and policy makers. Several studies have shown that in utero exposure to maternal filarial infections plays certain role in determining the susceptibility and disease outcome in children. But the mechanism of which has not been studied extensively. Therefore the present study was undertaken to understand the mechanism of immune modulation in children born to filarial infected mother in a MDA ongoing area.To our knowledge this is the first study to conduct both cellular and humoral immunological assays and follow up the children until older age in a W bancrofti endemic area,where the microfilariae (Mf) rate has come down to <1% after 10 rounds of MDA. A total 57 (32: born to infected, 25: born to uninfected mother) children were followed up. The infection status of children was measured by presence of Mf and circulating filarial antigen (CFA) assay. Filaria specific IgG1, IgG2, IgG3 and IgG4 responses were measured by ELISA. Plasma level of IL-10 and IFN-γ were evaluated by using commercially available ELISA kit. The study reveals a high rate of acquisition of filarial infection among the children born to infected mother compared to uninfected mothers. A significantly high level of IgG1 and IgG4 was observed in children born to infected mother, whereas high level of IgG3 was marked in children born to uninfected mother. Significantly high level of IL-10 positively correlated with IgG4 have been observed in infected children born to infected mother, while high level of IFN-γ positively correlated with IgG3 was found in infection free children born to mother free from infection at the time of pregnancy. Moreover a negative correlation between IL-10 and IFN-γ has been observed only among the infected children born to infected mother.The study shows a causal association between maternal filarial infection and impaired or altered immune response in children more susceptible to filarial infection during early childhood. As lymphatic damage that commences in childhood during asymptomatic stage has major implications from public health point of view, understanding maternal programming of the newborn immune system could provide a basis for interventions promoting child health by implementing MDA campaigns towards all women of childbearing age and young children in achieving the target of global elimination of LF." @default.
• W2893645079 created "2018-10-05" @default.
• W2893645079 creator A5001132661 @default.
• W2893645079 creator A5005037583 @default.
• W2893645079 creator A5009430989 @default.
• W2893645079 creator A5055853996 @default.
• W2893645079 creator A5061858117 @default.
• W2893645079 date "2018-09-25" @default.
• W2893645079 modified "2023-10-11" @default.
• W2893645079 title "Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study" @default.
• W2893645079 cites W1964520429 @default.
• W2893645079 cites W1968832188 @default.
• W2893645079 cites W1981376031 @default.
• W2893645079 cites W1990592039 @default.
• W2893645079 cites W1990723041 @default.
• W2893645079 cites W1992218749 @default.
• W2893645079 cites W2000426353 @default.
• W2893645079 cites W2011094521 @default.
• W2893645079 cites W2011900918 @default.
• W2893645079 cites W2021547867 @default.
• W2893645079 cites W2046595127 @default.
• W2893645079 cites W2069210406 @default.
• W2893645079 cites W2070963789 @default.
• W2893645079 cites W2085064015 @default.
• W2893645079 cites W2098928855 @default.
• W2893645079 cites W2143631009 @default.
• W2893645079 cites W2144267046 @default.
• W2893645079 cites W2160559960 @default.
• W2893645079 cites W2164050132 @default.
• W2893645079 cites W2511479145 @default.
• W2893645079 cites W2555919727 @default.
• W2893645079 cites W2591800024 @default.
• W2893645079 cites W2764098312 @default.
• W2893645079 cites W2765419938 @default.
• W2893645079 cites W989957696 @default.
• W2893645079 doi "https://doi.org/10.1371/journal.pntd.0006824" @default.
• W2893645079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173457" @default.
• W2893645079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30252839" @default.
• W2893645079 hasPublicationYear "2018" @default.
• W2893645079 type Work @default.
• W2893645079 sameAs 2893645079 @default.
• W2893645079 citedByCount "3" @default.
• W2893645079 countsByYear W28936450792021 @default.
• W2893645079 countsByYear W28936450792022 @default.
• W2893645079 countsByYear W28936450792023 @default.
• W2893645079 crossrefType "journal-article" @default.
• W2893645079 hasAuthorship W2893645079A5001132661 @default.
• W2893645079 hasAuthorship W2893645079A5005037583 @default.
• W2893645079 hasAuthorship W2893645079A5009430989 @default.
• W2893645079 hasAuthorship W2893645079A5055853996 @default.
• W2893645079 hasAuthorship W2893645079A5061858117 @default.
• W2893645079 hasBestOaLocation W28936450791 @default.
• W2893645079 hasConcept C119599485 @default.
• W2893645079 hasConcept C126322002 @default.
• W2893645079 hasConcept C127413603 @default.
• W2893645079 hasConcept C147483822 @default.
• W2893645079 hasConcept C159654299 @default.
• W2893645079 hasConcept C165901193 @default.
• W2893645079 hasConcept C172680121 @default.
• W2893645079 hasConcept C201614185 @default.
• W2893645079 hasConcept C203014093 @default.
• W2893645079 hasConcept C2776158911 @default.
• W2893645079 hasConcept C2777629521 @default.
• W2893645079 hasConcept C2779134260 @default.
• W2893645079 hasConcept C2779234561 @default.
• W2893645079 hasConcept C2780133432 @default.
• W2893645079 hasConcept C2908647359 @default.
• W2893645079 hasConcept C42407357 @default.
• W2893645079 hasConcept C54355233 @default.
• W2893645079 hasConcept C71924100 @default.
• W2893645079 hasConcept C72563966 @default.
• W2893645079 hasConcept C761482 @default.
• W2893645079 hasConcept C86803240 @default.
• W2893645079 hasConcept C8891405 @default.
• W2893645079 hasConcept C99454951 @default.
• W2893645079 hasConceptScore W2893645079C119599485 @default.
• W2893645079 hasConceptScore W2893645079C126322002 @default.
• W2893645079 hasConceptScore W2893645079C127413603 @default.
• W2893645079 hasConceptScore W2893645079C147483822 @default.
• W2893645079 hasConceptScore W2893645079C159654299 @default.
• W2893645079 hasConceptScore W2893645079C165901193 @default.
• W2893645079 hasConceptScore W2893645079C172680121 @default.
• W2893645079 hasConceptScore W2893645079C201614185 @default.
• W2893645079 hasConceptScore W2893645079C203014093 @default.
• W2893645079 hasConceptScore W2893645079C2776158911 @default.
• W2893645079 hasConceptScore W2893645079C2777629521 @default.
• W2893645079 hasConceptScore W2893645079C2779134260 @default.
• W2893645079 hasConceptScore W2893645079C2779234561 @default.
• W2893645079 hasConceptScore W2893645079C2780133432 @default.
• W2893645079 hasConceptScore W2893645079C2908647359 @default.
• W2893645079 hasConceptScore W2893645079C42407357 @default.
• W2893645079 hasConceptScore W2893645079C54355233 @default.
• W2893645079 hasConceptScore W2893645079C71924100 @default.
• W2893645079 hasConceptScore W2893645079C72563966 @default.
• W2893645079 hasConceptScore W2893645079C761482 @default.
• W2893645079 hasConceptScore W2893645079C86803240 @default.
• W2893645079 hasConceptScore W2893645079C8891405 @default.
• W2893645079 hasConceptScore W2893645079C99454951 @default.

• next