Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893649877> ?p ?o ?g. }
- W2893649877 endingPage "179" @default.
- W2893649877 startingPage "169" @default.
- W2893649877 abstract "Patients with cancer are at high risk of developing venous thromboembolism (VTE). Although the recommended low molecular weight heparins (LMWHs) are more effective than vitamin K antagonists in treating VTE in patients with cancer, they have limitations and contraindications. Direct oral anticoagulants (DOACs) circumvent some of these limitations. Here, DOAC use for VTE treatment in patients receiving anticancer therapy is reviewed, focusing on metabolic and elimination pathways, potential drug–drug interactions and practical considerations. DOACs are typically substrates of the cytochrome P450-based metabolic pathways and/or ATP-binding cassette transporters. Although many cancer therapies influence these pathways, only a minority of these drugs interact with DOACs. Phase III DOAC trials provided encouraging safety and efficacy data for their use in cancer-associated thrombosis. Furthermore, numerous ongoing DOAC trials strive to gain a better understanding of the treatment of cancer-associated thrombosis and continue to support a role for DOACs in this setting." @default.
- W2893649877 created "2018-10-05" @default.
- W2893649877 creator A5013296898 @default.
- W2893649877 creator A5015917994 @default.
- W2893649877 creator A5040991094 @default.
- W2893649877 creator A5045714331 @default.
- W2893649877 creator A5089208862 @default.
- W2893649877 date "2018-12-01" @default.
- W2893649877 modified "2023-10-05" @default.
- W2893649877 title "Direct oral anticoagulants for the treatment of venous thromboembolism in cancer patients: Potential for drug–drug interactions" @default.
- W2893649877 cites W1517107864 @default.
- W2893649877 cites W1584368083 @default.
- W2893649877 cites W1634950970 @default.
- W2893649877 cites W1834574045 @default.
- W2893649877 cites W1984833612 @default.
- W2893649877 cites W1994421979 @default.
- W2893649877 cites W2017582897 @default.
- W2893649877 cites W2020576239 @default.
- W2893649877 cites W2027863730 @default.
- W2893649877 cites W2029888371 @default.
- W2893649877 cites W2040496666 @default.
- W2893649877 cites W2056208055 @default.
- W2893649877 cites W2063853621 @default.
- W2893649877 cites W2064070223 @default.
- W2893649877 cites W2068476516 @default.
- W2893649877 cites W2089737020 @default.
- W2893649877 cites W2093389482 @default.
- W2893649877 cites W2094800902 @default.
- W2893649877 cites W2096592200 @default.
- W2893649877 cites W2115019673 @default.
- W2893649877 cites W2120203545 @default.
- W2893649877 cites W2120794058 @default.
- W2893649877 cites W2123448465 @default.
- W2893649877 cites W2132100672 @default.
- W2893649877 cites W2135700027 @default.
- W2893649877 cites W2135936995 @default.
- W2893649877 cites W2145431191 @default.
- W2893649877 cites W2147143600 @default.
- W2893649877 cites W2151349963 @default.
- W2893649877 cites W2154738014 @default.
- W2893649877 cites W2167494200 @default.
- W2893649877 cites W2225937646 @default.
- W2893649877 cites W2261070961 @default.
- W2893649877 cites W2263934434 @default.
- W2893649877 cites W2291575320 @default.
- W2893649877 cites W2298759858 @default.
- W2893649877 cites W2323297041 @default.
- W2893649877 cites W2471363772 @default.
- W2893649877 cites W2509795914 @default.
- W2893649877 cites W2524077168 @default.
- W2893649877 cites W2529469085 @default.
- W2893649877 cites W2619103901 @default.
- W2893649877 cites W2638761751 @default.
- W2893649877 cites W2727132522 @default.
- W2893649877 cites W2749505140 @default.
- W2893649877 cites W2764121201 @default.
- W2893649877 cites W2775434460 @default.
- W2893649877 cites W2787309434 @default.
- W2893649877 cites W2802130786 @default.
- W2893649877 cites W2891329981 @default.
- W2893649877 cites W2980301216 @default.
- W2893649877 cites W4205645630 @default.
- W2893649877 cites W4240119833 @default.
- W2893649877 cites W4247355438 @default.
- W2893649877 doi "https://doi.org/10.1016/j.critrevonc.2018.09.015" @default.
- W2893649877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30447923" @default.
- W2893649877 hasPublicationYear "2018" @default.
- W2893649877 type Work @default.
- W2893649877 sameAs 2893649877 @default.
- W2893649877 citedByCount "38" @default.
- W2893649877 countsByYear W28936498772019 @default.
- W2893649877 countsByYear W28936498772020 @default.
- W2893649877 countsByYear W28936498772021 @default.
- W2893649877 countsByYear W28936498772022 @default.
- W2893649877 countsByYear W28936498772023 @default.
- W2893649877 crossrefType "journal-article" @default.
- W2893649877 hasAuthorship W2893649877A5013296898 @default.
- W2893649877 hasAuthorship W2893649877A5015917994 @default.
- W2893649877 hasAuthorship W2893649877A5040991094 @default.
- W2893649877 hasAuthorship W2893649877A5045714331 @default.
- W2893649877 hasAuthorship W2893649877A5089208862 @default.
- W2893649877 hasConcept C121608353 @default.
- W2893649877 hasConcept C126322002 @default.
- W2893649877 hasConcept C177713679 @default.
- W2893649877 hasConcept C2776301958 @default.
- W2893649877 hasConcept C2776704044 @default.
- W2893649877 hasConcept C2778661090 @default.
- W2893649877 hasConcept C2779161974 @default.
- W2893649877 hasConcept C2780035454 @default.
- W2893649877 hasConcept C2780290652 @default.
- W2893649877 hasConcept C2780868729 @default.
- W2893649877 hasConcept C2991741193 @default.
- W2893649877 hasConcept C60644358 @default.
- W2893649877 hasConcept C71924100 @default.
- W2893649877 hasConcept C86803240 @default.
- W2893649877 hasConcept C98274493 @default.
- W2893649877 hasConceptScore W2893649877C121608353 @default.
- W2893649877 hasConceptScore W2893649877C126322002 @default.