FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893650274> ?p ?o ?g. }

• W2893650274 endingPage "3769" @default.
• W2893650274 startingPage "3763" @default.
• W2893650274 abstract "To alleviate concerns in health security, emergency flu vaccine stockpiles are required for ensuring rapid availability of vaccines when needed. Cold chain preservation, at high cost and risk, is necessary to maintain vaccine efficacy. This study aimed to develop a dry, easily storable formula for influenza vaccine preparation. The formulation with mucoadhesive properties is expected to facilitate rapid delivery via nasal administration. Chitosan, a cationic polymer, was used as cryo-protectant and to promote mucoadhesion. Optimal concentrations and molecular weights of chitosan polymers were screened, with short chain chitosan (10 kDa) being most suitable. H1N1 dry powder, in different formulations, was prepared via freeze-drying. A series of cryo-protectants, trehalose (T), chitosan (C), fetal bovine serum (FBS; F), or a combination of these (TCF), were screened for their effects on prolonging vaccine shelf life. Physicochemical monitoring (particle size and zeta potential) of powders complexed with mucin revealed that the order of cryo-protectant mixing during preparation was of critical importance. Results indicated that the TCF formula retains its activity up to 1 year as indicated by TCID50 analysis. This approach was also successful at prolonging the shelf life of H3N2 vaccine, and has the potential for large-scale implementation, especially in developed countries where long-term storage of vaccines is problematic." @default.
• W2893650274 created "2018-10-05" @default.
• W2893650274 creator A5014992399 @default.
• W2893650274 creator A5016350928 @default.
• W2893650274 creator A5024051438 @default.
• W2893650274 creator A5028377391 @default.
• W2893650274 creator A5039159399 @default.
• W2893650274 creator A5040497332 @default.
• W2893650274 creator A5051111931 @default.
• W2893650274 date "2018-09-26" @default.
• W2893650274 modified "2023-10-03" @default.
• W2893650274 title "Dry Formulations Enhanced Mucoadhesive Properties and Reduced Cold Chain Handing of Influenza Vaccines" @default.
• W2893650274 cites W1482864094 @default.
• W2893650274 cites W1703605928 @default.
• W2893650274 cites W1963498445 @default.
• W2893650274 cites W1971924504 @default.
• W2893650274 cites W1975350613 @default.
• W2893650274 cites W1984521944 @default.
• W2893650274 cites W1985117052 @default.
• W2893650274 cites W2008380945 @default.
• W2893650274 cites W2013224903 @default.
• W2893650274 cites W2021459906 @default.
• W2893650274 cites W2027231861 @default.
• W2893650274 cites W2030796658 @default.
• W2893650274 cites W2043168279 @default.
• W2893650274 cites W2047917046 @default.
• W2893650274 cites W2048795790 @default.
• W2893650274 cites W2057144911 @default.
• W2893650274 cites W2057530052 @default.
• W2893650274 cites W2065275168 @default.
• W2893650274 cites W2073776896 @default.
• W2893650274 cites W2077332396 @default.
• W2893650274 cites W2082093305 @default.
• W2893650274 cites W2102060349 @default.
• W2893650274 cites W2113283581 @default.
• W2893650274 cites W2113818197 @default.
• W2893650274 cites W2127519720 @default.
• W2893650274 cites W2150110259 @default.
• W2893650274 cites W2169383781 @default.
• W2893650274 cites W2198074726 @default.
• W2893650274 cites W2256756668 @default.
• W2893650274 doi "https://doi.org/10.1208/s12249-018-1181-2" @default.
• W2893650274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259401" @default.
• W2893650274 hasPublicationYear "2018" @default.
• W2893650274 type Work @default.
• W2893650274 sameAs 2893650274 @default.
• W2893650274 citedByCount "3" @default.
• W2893650274 countsByYear W28936502742020 @default.
• W2893650274 countsByYear W28936502742021 @default.
• W2893650274 countsByYear W28936502742022 @default.
• W2893650274 crossrefType "journal-article" @default.
• W2893650274 hasAuthorship W2893650274A5014992399 @default.
• W2893650274 hasAuthorship W2893650274A5016350928 @default.
• W2893650274 hasAuthorship W2893650274A5024051438 @default.
• W2893650274 hasAuthorship W2893650274A5028377391 @default.
• W2893650274 hasAuthorship W2893650274A5039159399 @default.
• W2893650274 hasAuthorship W2893650274A5040497332 @default.
• W2893650274 hasAuthorship W2893650274A5051111931 @default.
• W2893650274 hasBestOaLocation W28936502741 @default.
• W2893650274 hasConcept C105702510 @default.
• W2893650274 hasConcept C115930662 @default.
• W2893650274 hasConcept C13245373 @default.
• W2893650274 hasConcept C155672457 @default.
• W2893650274 hasConcept C159047783 @default.
• W2893650274 hasConcept C171250308 @default.
• W2893650274 hasConcept C178790620 @default.
• W2893650274 hasConcept C185592680 @default.
• W2893650274 hasConcept C192562407 @default.
• W2893650274 hasConcept C22070199 @default.
• W2893650274 hasConcept C2776954882 @default.
• W2893650274 hasConcept C2779732960 @default.
• W2893650274 hasConcept C2779820397 @default.
• W2893650274 hasConcept C2780020223 @default.
• W2893650274 hasConcept C2780114722 @default.
• W2893650274 hasConcept C2780689484 @default.
• W2893650274 hasConcept C31903555 @default.
• W2893650274 hasConcept C71924100 @default.
• W2893650274 hasConcept C82085835 @default.
• W2893650274 hasConcept C85663871 @default.
• W2893650274 hasConcept C86181022 @default.
• W2893650274 hasConceptScore W2893650274C105702510 @default.
• W2893650274 hasConceptScore W2893650274C115930662 @default.
• W2893650274 hasConceptScore W2893650274C13245373 @default.
• W2893650274 hasConceptScore W2893650274C155672457 @default.
• W2893650274 hasConceptScore W2893650274C159047783 @default.
• W2893650274 hasConceptScore W2893650274C171250308 @default.
• W2893650274 hasConceptScore W2893650274C178790620 @default.
• W2893650274 hasConceptScore W2893650274C185592680 @default.
• W2893650274 hasConceptScore W2893650274C192562407 @default.
• W2893650274 hasConceptScore W2893650274C22070199 @default.
• W2893650274 hasConceptScore W2893650274C2776954882 @default.
• W2893650274 hasConceptScore W2893650274C2779732960 @default.
• W2893650274 hasConceptScore W2893650274C2779820397 @default.
• W2893650274 hasConceptScore W2893650274C2780020223 @default.
• W2893650274 hasConceptScore W2893650274C2780114722 @default.
• W2893650274 hasConceptScore W2893650274C2780689484 @default.
• W2893650274 hasConceptScore W2893650274C31903555 @default.
• W2893650274 hasConceptScore W2893650274C71924100 @default.

• next