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- W2893652269 abstract "Objective: Dose optimization and pharmacokinetic evaluation of alpha emitting Radium-223 dichloride ( 223 RaCl 2 ) by planar gamma camera or single photon emission computed tomographic (SPECT) imaging are hampered by the low photon abundance and injection activities. Here, we demonstrate SPECT of 223 Ra using phantoms and small animal in vivo models. Methods: Line phantoms and mice bearing 223 Ra were imaged using a next generation dedicated small animal SPECT by detecting the low energy photon emissions from 223 Ra. Localization of the therapeutic agent was verified by whole body and whole limb autoradiography and its effect determined by immunofluorescence. Results: A state-of-the-art commercial small animal SPECT system equipped with a highly sensitive collimator enables collection of sufficient counts for three-dimensional reconstruction. Line sources of 223 Ra in both air and in a water scattering phantom gave linear response functions with provide full-width-at-half-maximum of 1.45 mm. Early and late phase imaging of the pharmacokinetics of the radiopharmaceutical were captured. Uptake at sites of active bone remodeling were correlated with DNA damage from the alpha particle emissions. Conclusions: This work demonstrates the capability to noninvasively define the distribution of 223 Ra, a recently approved alpha emitting radionuclide. This approach allows quantitative assessment of 223 Ra distribution and may provide radiation dose optimization strategies to improve therapeutic response and ultimately to enable personalized treatment planning." @default.
- W2893652269 created "2018-10-05" @default.
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- W2893652269 date "2018-09-26" @default.
- W2893652269 modified "2023-10-16" @default.
- W2893652269 title "First Whole-Body Three-Dimensional Tomographic Imaging of Alpha Particle Emitting Radium-223" @default.
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- W2893652269 doi "https://doi.org/10.1101/414649" @default.
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