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• W2893653677 abstract "Significance The neural substrate for “sleepiness,” as well as the molecular mechanisms determining daily sleep amounts, remain mysterious. Here, we found that a single amino acid, S551, of the protein kinase SIK3 has a crucial role in the regulation of sleep need and daily nonrapid-eye movement sleep amounts. Importantly, S551 in SIK3 is evolutionally conserved as a PKA phosphorylation site from nematodes and fruit flies to mice and humans. These findings implicate SIK3 in the molecular basis of homeostatic sleep/wake regulation." @default.
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• W2893653677 date "2018-09-25" @default.
• W2893653677 modified "2023-10-16" @default.
• W2893653677 title "A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice" @default.
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• W2893653677 doi "https://doi.org/10.1073/pnas.1810823115" @default.
• W2893653677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187192" @default.
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