FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893657393> ?p ?o ?g. }

• W2893657393 endingPage "211" @default.
• W2893657393 startingPage "202" @default.
• W2893657393 abstract "The present active pharmaceutical ingredient (API) is a lipophilic compound with a significant risk of not achieving therapeutic plasma concentrations due to solubility-limited absorption. The aim of the presented studies was to investigate whether three novel salts of a new selected candidate in the cardiovascular therapy area could be applied to improve intestinal absorption and the subsequent in vivo exposure. Three salts (chloride, hydrogen sulfate, and hemi-1.5-naphtalenedisulphonate) of the compound were manufactured and investigated regarding solubility, dissolution rate, and in vivo exposure in rats. The chemical and physical stability of the salt forms (and the crystalline parent compound) were followed in solid state, when dissolved and when formulated as microsuspensions. All salts showed improved solubility in investigated media, increased dissolution rate, and elevated in vivo exposures compared to a nanocrystal formulation (top-down) of the parent free base of the compound. The chloride- and the hydrogen sulfate salts of the API showed similar patterns regarding the chemical stability in solid state as the crystalline free base, while the salt formed of the hemi-1.5-naphtalenedisulphonic acid showed significantly improved stability. In conclusion, this study showed that three salts of a new selected candidate drug could be used to improve solubility, increase dissolution rate, and enhance oral absorption compared with a more commonly used nanocrystal formulation of the API. However, the identity of the counter ion appeared to be of less importance. On the other hand, only the salt of the hemi-1.5-naphtalenedisulphonic acid seemed to improve chemical stability compared with the API." @default.
• W2893657393 created "2018-10-05" @default.
• W2893657393 creator A5008514717 @default.
• W2893657393 creator A5044988976 @default.
• W2893657393 creator A5047380942 @default.
• W2893657393 creator A5048549915 @default.
• W2893657393 date "2018-10-17" @default.
• W2893657393 modified "2023-09-24" @default.
• W2893657393 title "A case study where pharmaceutical salts were used to address the issue of low <i>in vivo</i> exposure" @default.
• W2893657393 cites W1498305210 @default.
• W2893657393 cites W1979063088 @default.
• W2893657393 cites W1979828007 @default.
• W2893657393 cites W2001454290 @default.
• W2893657393 cites W2001533174 @default.
• W2893657393 cites W2001596955 @default.
• W2893657393 cites W2013066396 @default.
• W2893657393 cites W2016103258 @default.
• W2893657393 cites W2016971948 @default.
• W2893657393 cites W2017354662 @default.
• W2893657393 cites W2017883113 @default.
• W2893657393 cites W2018850356 @default.
• W2893657393 cites W2021226988 @default.
• W2893657393 cites W2028883574 @default.
• W2893657393 cites W2039493345 @default.
• W2893657393 cites W2041552222 @default.
• W2893657393 cites W2054260281 @default.
• W2893657393 cites W2057584545 @default.
• W2893657393 cites W2061313928 @default.
• W2893657393 cites W2064802984 @default.
• W2893657393 cites W2072432140 @default.
• W2893657393 cites W2076539410 @default.
• W2893657393 cites W2077895165 @default.
• W2893657393 cites W2082697065 @default.
• W2893657393 cites W2086390326 @default.
• W2893657393 cites W2144194950 @default.
• W2893657393 cites W2149120424 @default.
• W2893657393 cites W2170933357 @default.
• W2893657393 cites W2534060894 @default.
• W2893657393 cites W2556496813 @default.
• W2893657393 cites W2560056183 @default.
• W2893657393 cites W2564842213 @default.
• W2893657393 cites W2599075827 @default.
• W2893657393 cites W2765842885 @default.
• W2893657393 cites W2885642231 @default.
• W2893657393 cites W2952528349 @default.
• W2893657393 cites W3021953557 @default.
• W2893657393 doi "https://doi.org/10.1080/03639045.2018.1529184" @default.
• W2893657393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256689" @default.
• W2893657393 hasPublicationYear "2018" @default.
• W2893657393 type Work @default.
• W2893657393 sameAs 2893657393 @default.
• W2893657393 citedByCount "3" @default.
• W2893657393 countsByYear W28936573932020 @default.
• W2893657393 countsByYear W28936573932021 @default.
• W2893657393 crossrefType "journal-article" @default.
• W2893657393 hasAuthorship W2893657393A5008514717 @default.
• W2893657393 hasAuthorship W2893657393A5044988976 @default.
• W2893657393 hasAuthorship W2893657393A5047380942 @default.
• W2893657393 hasAuthorship W2893657393A5048549915 @default.
• W2893657393 hasConcept C116858620 @default.
• W2893657393 hasConcept C125287762 @default.
• W2893657393 hasConcept C13965031 @default.
• W2893657393 hasConcept C150903083 @default.
• W2893657393 hasConcept C155574463 @default.
• W2893657393 hasConcept C159985019 @default.
• W2893657393 hasConcept C178790620 @default.
• W2893657393 hasConcept C185592680 @default.
• W2893657393 hasConcept C186399102 @default.
• W2893657393 hasConcept C192562407 @default.
• W2893657393 hasConcept C207001950 @default.
• W2893657393 hasConcept C2776371256 @default.
• W2893657393 hasConcept C2778343803 @default.
• W2893657393 hasConcept C2778695967 @default.
• W2893657393 hasConcept C2780471494 @default.
• W2893657393 hasConcept C2780589914 @default.
• W2893657393 hasConcept C31903555 @default.
• W2893657393 hasConcept C43617362 @default.
• W2893657393 hasConcept C45904493 @default.
• W2893657393 hasConcept C71924100 @default.
• W2893657393 hasConcept C86803240 @default.
• W2893657393 hasConcept C88380143 @default.
• W2893657393 hasConcept C98274493 @default.
• W2893657393 hasConceptScore W2893657393C116858620 @default.
• W2893657393 hasConceptScore W2893657393C125287762 @default.
• W2893657393 hasConceptScore W2893657393C13965031 @default.
• W2893657393 hasConceptScore W2893657393C150903083 @default.
• W2893657393 hasConceptScore W2893657393C155574463 @default.
• W2893657393 hasConceptScore W2893657393C159985019 @default.
• W2893657393 hasConceptScore W2893657393C178790620 @default.
• W2893657393 hasConceptScore W2893657393C185592680 @default.
• W2893657393 hasConceptScore W2893657393C186399102 @default.
• W2893657393 hasConceptScore W2893657393C192562407 @default.
• W2893657393 hasConceptScore W2893657393C207001950 @default.
• W2893657393 hasConceptScore W2893657393C2776371256 @default.
• W2893657393 hasConceptScore W2893657393C2778343803 @default.
• W2893657393 hasConceptScore W2893657393C2778695967 @default.
• W2893657393 hasConceptScore W2893657393C2780471494 @default.
• W2893657393 hasConceptScore W2893657393C2780589914 @default.

• next