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• W2893662882 abstract "The White Collar complex is responsible for sensing light and transmitting that signal in many fungal species. In Cryptococcus neoformans and C. deneoformans the complex is involved in protection against damage from ultraviolet (UV) light, repression of mating in response to light, and is also required for virulence. The mechanism by which the Bwc1 photoreceptor contributes to virulence is unknown. In this study, a bwc1 deletion mutant of C. neoformans was transformed with three versions of the BWC1 gene, the wild type, BWC1C605A or BWC1C605S, in which the latter two have the conserved cysteine residue replaced with either alanine or serine within the light-oxygen-voltage (LOV) domain that interacts with the flavin chromophore. The bwc1+ BWC1 strain complemented the UV sensitivity and the repression of mating in the light. The bwc1+ BWC1C605A and bwc1+ BWC1C605S strains were not fully complemented for either of the phenotypes, indicating that these BWC1 alleles impair the light responses for strains with them. Transcript analysis showed that neither of the mutated strains (bwc1+ BWC1C605A and bwc1+ BWC1C605S) showed the light-inducible expression pattern of the HEM15 and UVE1 genes as occurs in the wild type strain. These results indicate that the conserved flavin-binding site in the LOV domain of Bwc1 is required for sensing and responding to light in C. neoformans. In contrast to defects in light responses, the wild type, bwc1+ BWC1, bwc1+ BWC1C605A and bwc1+ BWC1C605S strains were equally virulent, whereas the bwc1 knock out mutant was less virulent. Furthermore, pre-exposure of the strains to light prior to inoculation had no influence on the outcome of infection. These findings define a division in function of the White Collar complex in fungi, in that in C. neoformans the role of Bwc1 in virulence is independent of light sensing." @default.
• W2893662882 created "2018-10-05" @default.
• W2893662882 creator A5041480089 @default.
• W2893662882 creator A5070444328 @default.
• W2893662882 date "2018-12-01" @default.
• W2893662882 modified "2023-09-24" @default.
• W2893662882 title "The contribution of the White Collar complex to Cryptococcus neoformans virulence is independent of its light-sensing capabilities" @default.
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• W2893662882 doi "https://doi.org/10.1016/j.fgb.2018.09.008" @default.
• W2893662882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6252129" @default.
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• W2893662882 hasPublicationYear "2018" @default.
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