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- W2893665301 endingPage "4242" @default.
- W2893665301 startingPage "4236" @default.
- W2893665301 abstract "A complex DNA repair machinery has evolved to protect genomic integrity in the face of a myriad of DNA damage sources. When DNA repair fails, this damage can lead to carcinogenesis and tumor genomic instability. Indeed, many heritable cancer predisposition syndromes are attributable to germline defects in DNA repair pathways. On the other hand, these defects may also portend particular vulnerabilities of the cancer and may be exploited therapeutically. Most recently this has been demonstrated in the case of mismatch repair-deficient cancers, in which the immune checkpoint inhibitors have been demonstrated to be highly active. This observation has paved the way for further research investigating other sources of genomic instability that may serve as biomarkers to select patients for immunotherapy." @default.
- W2893665301 created "2018-10-05" @default.
- W2893665301 creator A5011776853 @default.
- W2893665301 creator A5084756293 @default.
- W2893665301 date "2018-10-01" @default.
- W2893665301 modified "2023-10-17" @default.
- W2893665301 title "DNA repair defects and implications for immunotherapy" @default.
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- W2893665301 doi "https://doi.org/10.1172/jci122010" @default.
- W2893665301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6159999" @default.
- W2893665301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272580" @default.