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- W2893667832 abstract "Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca2+ channel toxin present in Tityus serrulatus (Ts) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increases intracellular Ca2+ release through the activation of nuclear InsP3R of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells. Besides proposing a novel subfamily of Ca2+ active toxins, we investigated its potential use as a drug delivery system targeting cancer cell nucleus using CPP-Ts's nuclear-targeting property. To this end, we prepared a synthetic CPP-Ts sub peptide14-39 lacking pharmacological activity which was directed to the nucleus of specific cancer cell lines. This research identifies a novel subfamily of Ca2+ active toxins and provides new insights into biotechnological applications of animal venoms." @default.
- W2893667832 created "2018-10-05" @default.
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- W2893667832 date "2018-10-03" @default.
- W2893667832 modified "2023-10-18" @default.
- W2893667832 title "CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells" @default.
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- W2893667832 doi "https://doi.org/10.1038/s41598-018-33133-3" @default.
- W2893667832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170434" @default.
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- W2893667832 hasPublicationYear "2018" @default.
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