FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893671009> ?p ?o ?g. }

• W2893671009 endingPage "1560" @default.
• W2893671009 startingPage "1548" @default.
• W2893671009 abstract "New sources of insulin-secreting cells are strongly in demand for treatment of diabetes. Induced pluripotent stem cells (iPSCs) have the potential to generate insulin-producing cells (iβ). However, the gene expression profile and secretory function of iβ still need to be validated in comparison with native β cells.Two clones of human iPSCs, reprogrammed from adult fibroblasts through integration-free Sendai virus, were differentiated into iβ and compared with donor pancreatic islets and EndoC-βH1, an immortalized human β cell line.Both clones of iPSCs differentiated into insulin+ cells with high efficiency (up to 20%). iβ were negative for pluripotency markers (Oct4, Sox2, Ssea4) and positive for Pdx1, Nkx6.1, Chromogranin A, PC1/3, insulin, glucagon and somatostatin. iβ basally secreted C-peptide, glucagon and ghrelin and released insulin in response either to increasing concentration of glucose or a depolarizing stimulus. The comparison revealed that iβ are remarkably similar to donor derived islets in terms of gene and protein expression profile and similar level of heterogeneity. The ability of iβ to respond to glucose instead was more related to that of EndoC-βH1.We demonstrated that insulin-producing cells generated from iPSCs recapitulate fundamental gene expression profiles and secretory function of native human β cells." @default.
• W2893671009 created "2018-10-05" @default.
• W2893671009 creator A5005129014 @default.
• W2893671009 creator A5022588272 @default.
• W2893671009 creator A5026653409 @default.
• W2893671009 creator A5034358422 @default.
• W2893671009 creator A5053425047 @default.
• W2893671009 creator A5057257184 @default.
• W2893671009 creator A5057911115 @default.
• W2893671009 creator A5060623848 @default.
• W2893671009 creator A5071355864 @default.
• W2893671009 creator A5079051825 @default.
• W2893671009 date "2018-09-25" @default.
• W2893671009 modified "2023-10-15" @default.
• W2893671009 title "Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line" @default.
• W2893671009 cites W1967025085 @default.
• W2893671009 cites W1969918210 @default.
• W2893671009 cites W1972766500 @default.
• W2893671009 cites W2029004494 @default.
• W2893671009 cites W2032472678 @default.
• W2893671009 cites W2038404321 @default.
• W2893671009 cites W2043304304 @default.
• W2893671009 cites W2049820630 @default.
• W2893671009 cites W2054361177 @default.
• W2893671009 cites W2055492712 @default.
• W2893671009 cites W2058601364 @default.
• W2893671009 cites W2062573090 @default.
• W2893671009 cites W2079205293 @default.
• W2893671009 cites W2089593092 @default.
• W2893671009 cites W2106219965 @default.
• W2893671009 cites W2125987139 @default.
• W2893671009 cites W2129387684 @default.
• W2893671009 cites W2131635560 @default.
• W2893671009 cites W2138726422 @default.
• W2893671009 cites W2138977668 @default.
• W2893671009 cites W2148890861 @default.
• W2893671009 cites W2171678230 @default.
• W2893671009 cites W2225320923 @default.
• W2893671009 cites W2252442238 @default.
• W2893671009 cites W2281703724 @default.
• W2893671009 cites W2316384098 @default.
• W2893671009 cites W2341414956 @default.
• W2893671009 cites W2381312419 @default.
• W2893671009 cites W2461874209 @default.
• W2893671009 cites W2554650020 @default.
• W2893671009 cites W2613179652 @default.
• W2893671009 cites W2745506416 @default.
• W2893671009 cites W4234853498 @default.
• W2893671009 doi "https://doi.org/10.1177/0963689718798564" @default.
• W2893671009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180725" @default.
• W2893671009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30251567" @default.
• W2893671009 hasPublicationYear "2018" @default.
• W2893671009 type Work @default.
• W2893671009 sameAs 2893671009 @default.
• W2893671009 citedByCount "16" @default.
• W2893671009 countsByYear W28936710092020 @default.
• W2893671009 countsByYear W28936710092021 @default.
• W2893671009 countsByYear W28936710092022 @default.
• W2893671009 countsByYear W28936710092023 @default.
• W2893671009 crossrefType "journal-article" @default.
• W2893671009 hasAuthorship W2893671009A5005129014 @default.
• W2893671009 hasAuthorship W2893671009A5022588272 @default.
• W2893671009 hasAuthorship W2893671009A5026653409 @default.
• W2893671009 hasAuthorship W2893671009A5034358422 @default.
• W2893671009 hasAuthorship W2893671009A5053425047 @default.
• W2893671009 hasAuthorship W2893671009A5057257184 @default.
• W2893671009 hasAuthorship W2893671009A5057911115 @default.
• W2893671009 hasAuthorship W2893671009A5060623848 @default.
• W2893671009 hasAuthorship W2893671009A5071355864 @default.
• W2893671009 hasAuthorship W2893671009A5079051825 @default.
• W2893671009 hasBestOaLocation W28936710091 @default.
• W2893671009 hasConcept C104317684 @default.
• W2893671009 hasConcept C107459253 @default.
• W2893671009 hasConcept C121587040 @default.
• W2893671009 hasConcept C126322002 @default.
• W2893671009 hasConcept C134018914 @default.
• W2893671009 hasConcept C145103041 @default.
• W2893671009 hasConcept C148738053 @default.
• W2893671009 hasConcept C1491633281 @default.
• W2893671009 hasConcept C150194340 @default.
• W2893671009 hasConcept C165220095 @default.
• W2893671009 hasConcept C191370860 @default.
• W2893671009 hasConcept C2778265714 @default.
• W2893671009 hasConcept C2778563252 @default.
• W2893671009 hasConcept C2779050171 @default.
• W2893671009 hasConcept C2779306644 @default.
• W2893671009 hasConcept C2780127873 @default.
• W2893671009 hasConcept C54355233 @default.
• W2893671009 hasConcept C71924100 @default.
• W2893671009 hasConcept C77255625 @default.
• W2893671009 hasConcept C81885089 @default.
• W2893671009 hasConcept C86803240 @default.
• W2893671009 hasConcept C95444343 @default.
• W2893671009 hasConceptScore W2893671009C104317684 @default.
• W2893671009 hasConceptScore W2893671009C107459253 @default.
• W2893671009 hasConceptScore W2893671009C121587040 @default.
• W2893671009 hasConceptScore W2893671009C126322002 @default.
• W2893671009 hasConceptScore W2893671009C134018914 @default.

• next