FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893675460> ?p ?o ?g. }

• W2893675460 endingPage "1041" @default.
• W2893675460 startingPage "1023" @default.
• W2893675460 abstract "Despite major advances in kidney transplant, glucocorticoids (GCs) or steroids remain one of the mainstay treatments. They possess adverse events (AEs) that are related to cumulative dosage, as documented in experimental and clinical studies. Therefore, it is important to comprehend and interpret experimental data and equally important to critically review clinical studies. Areas covered: This article provides a broad overview of the structure, pharmacokinetics, and pharmacodynamics of systemically administered GCs in transplant setting. It further discusses at length the results of in vitro and pre-clinical studies, as well as steroid avoidance (SA) or withdrawal (SW)-based clinical studies. We summarized the main AEs and discussed the alternatives to minimize these events. Some clinically relevant drug-drug interactions are also highlighted. Expert opinion: Although SA/SW in kidney transplant is a desirable strategy due to its AEs, there is no evidence to support that strategy based on the available data, despite some encouraging reports. Furthermore, early diagnosis and treatment of GC-induced AEs seem to be the most efficacious strategies. Likewise, some risks factors predate transplant and could be used to risk-stratify patients to determine appropriate risk-reduction strategies. Additional randomized-controlled studies are required to assess the impact of SA/SW during short and long follow-ups.ACTH: Adrenocorticotropic hormone (also adrenocorticotropin and corticotropin); ADA: American Diabetes Association; AEs: Adverse events; ADX: Adrenalectomized; AR: Acute rejection; AUC: Area under the curve; BMI: Body mass index; BMD: Bone mineral density; BPAR: Biopsy-proven acute rejection; cAMP: cyclic adenosine monophospahte; CBG: Corticosteroid-binding globulin; CBP: CREB binding protein; Cmax: Mean maximal serum concentration; CNIs: Calcineurin inhibitors; COX-2: cyclo-oxygenase-2; cPLA2: cytosolic phospholipase A2; CSA: Cyclosporine; CYP: Cytochrome; DEX: Dexamethasone; DM: Diabetes mellitus; ESW: Early steroid withdrawal; GCs: Glucocorticoids; GRs: Glucocorticoid receptors; GREs: Glucocorticoid receptor elements; CSA: Cyclosporine; DEX: Dexamethasone; Glycated hemoglobin: HbA1c; HDL: High-density lipoproteins; HLA: Human leukocyte anrigen; HPA axis: Hypothalamic-pituitary-adrenal axis; HR: Hazard ratio; HSP: Heat shock proteins; 11β-HSD: 11β-Hydroxysteroid dehydrogenase; IC50: Half of maximal inhibitory concentration; IFG: Impaired fasting glucose; IGT: Impaired glucose tolerance; imTOR: Inhibitors of mammalian target of rapamycin; iNOS: Inducible oxide nitric synthase; Kd: Dissociation constant; KDIGO: Kidney Disease: Improving Global Outcomes; LSW: Late steroid withdrawal; LDL: Low-density lipoproteins; MCP-1: Monocyte chemoattractant protein-1; MMF: Mycophenolate mofetil; MPS: Mycophenolate sodium; NSAIDS: non-steroidal anti- inflammatory drugs; NF-κB: Nnuclear factor-κB TNF; OPTN/UNOS: Organ Procurement and Transplant Network/United Network of Organ Sharing database; PK/PD: Pharmacokinetic/pharmacodynamics; PRA: Panel reactive antibodies; PTDM: Post-transplantation diabetes mellitus; PTH: Parathyroid hormone; RCT: Randomized controlled trial; RR: Risk ratio; SA: Steroid avoidanceSGLT-2: Sodium-glucose co-transporter 2; SW: Steroid withdrawal; TAC: Tacrolimus or FK506; TG/HDL: Triglyceride to high-density lipoprotein ratio; TNF-α: Tumor necrosis factor-α; TGF-β: Transforming growth factor-β." @default.
• W2893675460 created "2018-10-05" @default.
• W2893675460 creator A5059676586 @default.
• W2893675460 creator A5068438396 @default.
• W2893675460 date "2018-10-03" @default.
• W2893675460 modified "2023-10-16" @default.
• W2893675460 title "Glucocorticoids use in kidney transplant setting" @default.
• W2893675460 cites W1482286587 @default.
• W2893675460 cites W1543301013 @default.
• W2893675460 cites W1572287703 @default.
• W2893675460 cites W1582154931 @default.
• W2893675460 cites W1605768991 @default.
• W2893675460 cites W1654748046 @default.
• W2893675460 cites W1755633921 @default.
• W2893675460 cites W1767457120 @default.
• W2893675460 cites W1917835527 @default.
• W2893675460 cites W1967692462 @default.
• W2893675460 cites W1968567860 @default.
• W2893675460 cites W1970604167 @default.
• W2893675460 cites W1971720167 @default.
• W2893675460 cites W1975450043 @default.
• W2893675460 cites W1976587178 @default.
• W2893675460 cites W1977375642 @default.
• W2893675460 cites W1977589132 @default.
• W2893675460 cites W1985498707 @default.
• W2893675460 cites W1989455153 @default.
• W2893675460 cites W1990903078 @default.
• W2893675460 cites W1994336149 @default.
• W2893675460 cites W2001155138 @default.
• W2893675460 cites W2001921478 @default.
• W2893675460 cites W2002315967 @default.
• W2893675460 cites W2004740828 @default.
• W2893675460 cites W2006211317 @default.
• W2893675460 cites W2008578164 @default.
• W2893675460 cites W2013233763 @default.
• W2893675460 cites W2016922039 @default.
• W2893675460 cites W2020702613 @default.
• W2893675460 cites W2021881836 @default.
• W2893675460 cites W2024369575 @default.
• W2893675460 cites W2026778629 @default.
• W2893675460 cites W2026860062 @default.
• W2893675460 cites W2032686039 @default.
• W2893675460 cites W2032943580 @default.
• W2893675460 cites W2034766774 @default.
• W2893675460 cites W2035324444 @default.
• W2893675460 cites W2036329535 @default.
• W2893675460 cites W2038598566 @default.
• W2893675460 cites W2039913375 @default.
• W2893675460 cites W2044600432 @default.
• W2893675460 cites W2045629927 @default.
• W2893675460 cites W2047250310 @default.
• W2893675460 cites W2052639424 @default.
• W2893675460 cites W2063871795 @default.
• W2893675460 cites W2066921262 @default.
• W2893675460 cites W2067330032 @default.
• W2893675460 cites W2067734799 @default.
• W2893675460 cites W2069554905 @default.
• W2893675460 cites W2069987842 @default.
• W2893675460 cites W2079911249 @default.
• W2893675460 cites W2080154421 @default.
• W2893675460 cites W2081814889 @default.
• W2893675460 cites W2081879247 @default.
• W2893675460 cites W2083202947 @default.
• W2893675460 cites W2088114577 @default.
• W2893675460 cites W2088546464 @default.
• W2893675460 cites W2089652950 @default.
• W2893675460 cites W2094664255 @default.
• W2893675460 cites W2096093008 @default.
• W2893675460 cites W2103127086 @default.
• W2893675460 cites W2108159318 @default.
• W2893675460 cites W2108647254 @default.
• W2893675460 cites W2108910350 @default.
• W2893675460 cites W2109380210 @default.
• W2893675460 cites W2109654520 @default.
• W2893675460 cites W2109781781 @default.
• W2893675460 cites W2119666961 @default.
• W2893675460 cites W2120095600 @default.
• W2893675460 cites W2122004550 @default.
• W2893675460 cites W2126105025 @default.
• W2893675460 cites W2129238157 @default.
• W2893675460 cites W2130465636 @default.
• W2893675460 cites W2130856157 @default.
• W2893675460 cites W2134363915 @default.
• W2893675460 cites W2134372027 @default.
• W2893675460 cites W2135719046 @default.
• W2893675460 cites W2137873612 @default.
• W2893675460 cites W2139830508 @default.
• W2893675460 cites W2141351444 @default.
• W2893675460 cites W2143722971 @default.
• W2893675460 cites W2143724469 @default.
• W2893675460 cites W2144478272 @default.
• W2893675460 cites W2146264128 @default.
• W2893675460 cites W2148381849 @default.
• W2893675460 cites W2156576798 @default.
• W2893675460 cites W2163383829 @default.
• W2893675460 cites W2166139086 @default.
• W2893675460 cites W2168286678 @default.
• W2893675460 cites W2168748542 @default.

• next