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• W2893676184 abstract "Neurotransmitter release is triggered by Ca2+ influx through voltage-dependent Ca2+ channels (VDCCs). Distinct expression patterns of VDCC subtypes localized on the synaptic terminal affect intracellular Ca2+ dynamics induced by action potential-triggered Ca2+ influx. However, it has been unknown whether the expression pattern of VDCC subtypes depends on each axon terminal or neuronal subtype. Furthermore, little information is available on how these VDCC subtypes regulate the release probability of neurotransmitters. To address these questions, we performed multiple whole-cell patch-clamp recordings from GABAergic neurons in the insular cortex of either the male or the female rat. The paired-pulse ratio (PPR; 50 ms interstimulus interval) varied widely among inhibitory connections between GABAergic neurons. The PPR of unitary IPSCs was enhanced by ω-conotoxin GVIA (CgTx; 3 μm), an N-type VDCC blocker, whereas blockade of P/Q-type VDCCs by ω-agatoxin IVA (AgTx, 200 nm) decreased the PPR. In the presence of CgTx, application of 4 mm [Ca2+]o or of roscovitine, a P/Q-type activator, increased the PPR. These results suggest that the recruitment of P/Q-type VDCCs increases the PPR, whereas N-type VDCCs suppress the PPR. Furthermore, we found that charybdotoxin or apamin, blockers of Ca2+-dependent K+ channels, with AgTx increased the PPR, suggesting that Ca2+-dependent K+ channels are coupled to N-type VDCCs and suppress the PPR in GABAergic neuronal terminals. Variance-mean analysis with changing [Ca2+]o showed a negative correlation between the PPR and release probability in GABAergic synapses. These results suggest that GABAergic neurons differentially express N-type and/or P/Q-type VDCCs and that these VDCCs regulate the GABA release probability in distinct manners.SIGNIFICANCE STATEMENT GABAergic neuronal axons target multiple neurons and release GABA triggered by Ca2+ influx via voltage-dependent Ca2+ channels (VDCCs), including N-type and P/Q-type channels. Little is known about VDCC expression patterns in GABAergic synaptic terminals and their role in short-term plasticity. We focused on inhibitory synaptic connections between GABAergic neurons in the cerebral cortex using multiple whole-cell patch-clamp recordings and found different expression patterns of VDCCs in the synaptic terminals branched from a single presynaptic neuron. Furthermore, we observed facilitative and depressive short-term plasticity of IPSCs mediated by P/Q-type and N-type VDCCs, respectively. These results suggest that VDCC expression patterns regulate distinctive types of synaptic transmission in each GABAergic axon terminal even though they are branched from a common presynaptic neuron." @default.
• W2893676184 created "2018-10-05" @default.
• W2893676184 creator A5033804823 @default.
• W2893676184 creator A5040199485 @default.
• W2893676184 date "2018-09-24" @default.
• W2893676184 modified "2023-10-14" @default.
• W2893676184 title "Opposite Roles in Short-Term Plasticity for N-Type and P/Q-Type Voltage-Dependent Calcium Channels in GABAergic Neuronal Connections in the Rat Cerebral Cortex" @default.
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• W2893676184 cites W1604744466 @default.
• W2893676184 cites W1671421450 @default.
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• W2893676184 cites W1970292539 @default.
• W2893676184 cites W1980325410 @default.
• W2893676184 cites W1984213418 @default.
• W2893676184 cites W1984290280 @default.
• W2893676184 cites W1985553704 @default.
• W2893676184 cites W1991890788 @default.
• W2893676184 cites W1992424371 @default.
• W2893676184 cites W1995254751 @default.
• W2893676184 cites W2012846394 @default.
• W2893676184 cites W2016880507 @default.
• W2893676184 cites W2027115204 @default.
• W2893676184 cites W2028679298 @default.
• W2893676184 cites W2031442407 @default.
• W2893676184 cites W2033486767 @default.
• W2893676184 cites W2036111481 @default.
• W2893676184 cites W2038359286 @default.
• W2893676184 cites W2039210066 @default.
• W2893676184 cites W2042615624 @default.
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• W2893676184 cites W2044797107 @default.
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• W2893676184 cites W2059675111 @default.
• W2893676184 cites W2060084426 @default.
• W2893676184 cites W2060175556 @default.
• W2893676184 cites W2064016110 @default.
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• W2893676184 cites W2113574370 @default.
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• W2893676184 doi "https://doi.org/10.1523/jneurosci.0337-18.2018" @default.
• W2893676184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596248" @default.
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• W2893676184 hasPublicationYear "2018" @default.
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