Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893677042> ?p ?o ?g. }
- W2893677042 endingPage "2759" @default.
- W2893677042 startingPage "2748" @default.
- W2893677042 abstract "Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational immunotherapy combinations. However, accessibility to the tumor prior and during therapy is a major limitation in understanding the immune tumor microenvironment (TME). Herein, we identified urine-derived lymphocytes (UDLs) as a readily accessible source of T cells in 32 patients with muscle invasive bladder cancer (MIBC). We observed that effector CD8+ and CD4+ cells and regulatory T cells within the urine accurately map the immune checkpoint landscape and T cell receptor repertoire of the TME. Finally, an increased UDL count, specifically high expression of PD-1 (PD-1hi) on CD8+ at the time of cystectomy, was associated with a shorter recurrence-free survival. UDL analysis represents a dynamic liquid biopsy that is representative of the bladder immune TME that may be used to identify actionable immuno-oncology (IO) targets with potential prognostic value in MIBC." @default.
- W2893677042 created "2018-10-05" @default.
- W2893677042 creator A5001737873 @default.
- W2893677042 creator A5001865369 @default.
- W2893677042 creator A5012800133 @default.
- W2893677042 creator A5016475369 @default.
- W2893677042 creator A5017654709 @default.
- W2893677042 creator A5020337250 @default.
- W2893677042 creator A5022192311 @default.
- W2893677042 creator A5027476082 @default.
- W2893677042 creator A5029987103 @default.
- W2893677042 creator A5035783276 @default.
- W2893677042 creator A5036452592 @default.
- W2893677042 creator A5038209629 @default.
- W2893677042 creator A5046491920 @default.
- W2893677042 creator A5054600574 @default.
- W2893677042 creator A5055015769 @default.
- W2893677042 creator A5055292391 @default.
- W2893677042 creator A5066998907 @default.
- W2893677042 creator A5069486348 @default.
- W2893677042 creator A5069893099 @default.
- W2893677042 creator A5079529426 @default.
- W2893677042 creator A5079640210 @default.
- W2893677042 creator A5080584855 @default.
- W2893677042 creator A5088514565 @default.
- W2893677042 creator A5089988286 @default.
- W2893677042 creator A5091064277 @default.
- W2893677042 date "2018-09-26" @default.
- W2893677042 modified "2023-10-16" @default.
- W2893677042 title "Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment" @default.
- W2893677042 cites W1910233653 @default.
- W2893677042 cites W1964586588 @default.
- W2893677042 cites W1965031244 @default.
- W2893677042 cites W1975918912 @default.
- W2893677042 cites W1980137951 @default.
- W2893677042 cites W1981528932 @default.
- W2893677042 cites W2037610638 @default.
- W2893677042 cites W2039123767 @default.
- W2893677042 cites W2049553585 @default.
- W2893677042 cites W2051227478 @default.
- W2893677042 cites W2076335749 @default.
- W2893677042 cites W2077116159 @default.
- W2893677042 cites W2089600290 @default.
- W2893677042 cites W2093773243 @default.
- W2893677042 cites W2104885590 @default.
- W2893677042 cites W2106747061 @default.
- W2893677042 cites W2107429737 @default.
- W2893677042 cites W2107598346 @default.
- W2893677042 cites W2124427232 @default.
- W2893677042 cites W2140323624 @default.
- W2893677042 cites W2141269240 @default.
- W2893677042 cites W2209095244 @default.
- W2893677042 cites W2239206886 @default.
- W2893677042 cites W2291298003 @default.
- W2893677042 cites W2371138393 @default.
- W2893677042 cites W2435243879 @default.
- W2893677042 cites W2512255557 @default.
- W2893677042 cites W2560367415 @default.
- W2893677042 cites W2582671354 @default.
- W2893677042 cites W2588916311 @default.
- W2893677042 cites W2745624257 @default.
- W2893677042 cites W2756279299 @default.
- W2893677042 cites W2757841853 @default.
- W2893677042 cites W2760661635 @default.
- W2893677042 cites W2763756177 @default.
- W2893677042 cites W2771737095 @default.
- W2893677042 cites W2777192533 @default.
- W2893677042 cites W2785803176 @default.
- W2893677042 cites W2799524849 @default.
- W2893677042 cites W2807534769 @default.
- W2893677042 cites W2808455729 @default.
- W2893677042 cites W4254345745 @default.
- W2893677042 doi "https://doi.org/10.1084/jem.20181003" @default.
- W2893677042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6219732" @default.
- W2893677042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257862" @default.
- W2893677042 hasPublicationYear "2018" @default.
- W2893677042 type Work @default.
- W2893677042 sameAs 2893677042 @default.
- W2893677042 citedByCount "31" @default.
- W2893677042 countsByYear W28936770422019 @default.
- W2893677042 countsByYear W28936770422020 @default.
- W2893677042 countsByYear W28936770422021 @default.
- W2893677042 countsByYear W28936770422022 @default.
- W2893677042 countsByYear W28936770422023 @default.
- W2893677042 crossrefType "journal-article" @default.
- W2893677042 hasAuthorship W2893677042A5001737873 @default.
- W2893677042 hasAuthorship W2893677042A5001865369 @default.
- W2893677042 hasAuthorship W2893677042A5012800133 @default.
- W2893677042 hasAuthorship W2893677042A5016475369 @default.
- W2893677042 hasAuthorship W2893677042A5017654709 @default.
- W2893677042 hasAuthorship W2893677042A5020337250 @default.
- W2893677042 hasAuthorship W2893677042A5022192311 @default.
- W2893677042 hasAuthorship W2893677042A5027476082 @default.
- W2893677042 hasAuthorship W2893677042A5029987103 @default.
- W2893677042 hasAuthorship W2893677042A5035783276 @default.
- W2893677042 hasAuthorship W2893677042A5036452592 @default.
- W2893677042 hasAuthorship W2893677042A5038209629 @default.
- W2893677042 hasAuthorship W2893677042A5046491920 @default.