Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893677181> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2893677181 endingPage "938" @default.
- W2893677181 startingPage "932" @default.
- W2893677181 abstract "It is well known that high-pressure carbon dioxide (CO2) lowers the glass transition temperature (Tg) of polymers. We therefore investigated whether Tg depression of high-pressure CO2 results in interparticle bridging of a polymer and the tablet characteristics that makes the manufacture of an orally disintegrating tablet (ODT) possible. Copolyvidone (Kollidon®) and polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus®) were examined and found to exhibit a large Tg depression. Placebo ODTs were prepared and hardness, disintegration rate, porosity, and change in thickness and appearance were evaluated before and after the high-pressure CO2 treatment. This enabled the establishment of the optimal conditions for pressure, temperature, and treatment time under pressure. Experimental results showed that it was possible to manufacture ODTs comprising Kollidon® as a water-soluble polymer with CO2 treatment under the suitable conditions such as temperature at 45°C, pressure lower than 8 MPa, and a treatment time shorter than 30 min, which is a new ODT manufacturing process called “Carbon Dioxide Assisted Tablet Formation Scheme” (CATS). In comparison to the conventional processes, which require high temperatures or humidity, CATS is expected to be applicable to drugs that are unstable at high temperature and humidity, and to functional drug particles used for bitter taste masking, sustained release, and other uses." @default.
- W2893677181 created "2018-10-05" @default.
- W2893677181 creator A5004653171 @default.
- W2893677181 creator A5016156286 @default.
- W2893677181 creator A5045091020 @default.
- W2893677181 creator A5051813155 @default.
- W2893677181 creator A5087304863 @default.
- W2893677181 date "2018-10-01" @default.
- W2893677181 modified "2023-10-02" @default.
- W2893677181 title "Novel Orally Disintegrating Tablets Produced Using a High-Pressure Carbon Dioxides Process" @default.
- W2893677181 cites W1823937713 @default.
- W2893677181 cites W1970176652 @default.
- W2893677181 doi "https://doi.org/10.1248/cpb.c18-00220" @default.
- W2893677181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270240" @default.
- W2893677181 hasPublicationYear "2018" @default.
- W2893677181 type Work @default.
- W2893677181 sameAs 2893677181 @default.
- W2893677181 citedByCount "0" @default.
- W2893677181 crossrefType "journal-article" @default.
- W2893677181 hasAuthorship W2893677181A5004653171 @default.
- W2893677181 hasAuthorship W2893677181A5016156286 @default.
- W2893677181 hasAuthorship W2893677181A5045091020 @default.
- W2893677181 hasAuthorship W2893677181A5051813155 @default.
- W2893677181 hasAuthorship W2893677181A5087304863 @default.
- W2893677181 hasBestOaLocation W28936771811 @default.
- W2893677181 hasConcept C127413603 @default.
- W2893677181 hasConcept C178790620 @default.
- W2893677181 hasConcept C185592680 @default.
- W2893677181 hasConcept C2776964284 @default.
- W2893677181 hasConcept C42360764 @default.
- W2893677181 hasConcept C43617362 @default.
- W2893677181 hasConcept C521977710 @default.
- W2893677181 hasConcept C77281830 @default.
- W2893677181 hasConceptScore W2893677181C127413603 @default.
- W2893677181 hasConceptScore W2893677181C178790620 @default.
- W2893677181 hasConceptScore W2893677181C185592680 @default.
- W2893677181 hasConceptScore W2893677181C2776964284 @default.
- W2893677181 hasConceptScore W2893677181C42360764 @default.
- W2893677181 hasConceptScore W2893677181C43617362 @default.
- W2893677181 hasConceptScore W2893677181C521977710 @default.
- W2893677181 hasConceptScore W2893677181C77281830 @default.
- W2893677181 hasIssue "10" @default.
- W2893677181 hasLocation W28936771811 @default.
- W2893677181 hasLocation W28936771812 @default.
- W2893677181 hasOpenAccess W2893677181 @default.
- W2893677181 hasPrimaryLocation W28936771811 @default.
- W2893677181 hasRelatedWork W1500954276 @default.
- W2893677181 hasRelatedWork W1985432865 @default.
- W2893677181 hasRelatedWork W2050776281 @default.
- W2893677181 hasRelatedWork W2063687218 @default.
- W2893677181 hasRelatedWork W2092488429 @default.
- W2893677181 hasRelatedWork W2748952813 @default.
- W2893677181 hasRelatedWork W2950701138 @default.
- W2893677181 hasRelatedWork W3085044440 @default.
- W2893677181 hasRelatedWork W4248512376 @default.
- W2893677181 hasRelatedWork W2461423394 @default.
- W2893677181 hasVolume "66" @default.
- W2893677181 isParatext "false" @default.
- W2893677181 isRetracted "false" @default.
- W2893677181 magId "2893677181" @default.
- W2893677181 workType "article" @default.