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- W2893678831 abstract "Abstract The management and treatment of cervical cancer, a leading cause of cancer-related female death, remains a significant public health issue worldwide. Cervical cancer is categorized into two subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (AC), which is a relatively rare form but more resistant to treatment. Therefore, new strategies to treat cervical cancer are urgently needed. In this chapter, the effects of apigenin both in vitro and in vivo on cervical cancer are discussed. A recent study conducted by the authors has shown that apigenin has a selective dose-dependent cytotoxic effect and could induce apoptosis in SiHa, CaSki, and C33A cells (derived from SCC), in HeLa (derived from AC), but not in HaCaT cells (nontumorigenic cells). Additionally, apigenin induced mitochondrial redox impairment and inhibited cancer cell migration and invasion. Taken together, these results and some others of recent studies suggest a selective therapeutic potential of apigenin for managing cervical SCC and AC." @default.
- W2893678831 created "2018-10-05" @default.
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- W2893678831 date "2018-01-01" @default.
- W2893678831 modified "2023-10-03" @default.
- W2893678831 title "The Polyphenolic Compound Apigenin and Applications to Cervical Cancer" @default.
- W2893678831 doi "https://doi.org/10.1016/b978-0-12-813008-7.00013-8" @default.
- W2893678831 hasPublicationYear "2018" @default.
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