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- W2893692955 abstract "Eight new platinum(II) complexes Pt1–Pt8 with substituted 3‑(2′‑benzimidazolyl) coumarins were successfully synthesized and characterized by single crystal X-ray diffraction analysis, nuclear magnetic resonance spectroscopy (NMR), electrospray ionization-mass spectrometry (ESI-MS), infrared spectrophotometry (IR) and elemental analysis. Crystallographic data of these Pt1–Pt8 complexes showed that the Pt(II) has distorted four-coordinated square planar geometry. Pt1–Pt8 were found to display high cytotoxic activity in vitro against the cisplatin-resistant SK-OV-3/DDP cancer cells with a low IC50 from 1.01–10.32 μM, but low cytotoxicity on the normal HL-7702 cells. Further studies revealed that Pt1–Pt3 induced apoptosis in SK-OV-3/DDP cancer cells via mitochondria dysfunction signaling pathways. Our findings also indicated that Pt1 was a telomerase inhibitor targeting c-myc promoter elements." @default.
- W2893692955 created "2018-10-05" @default.
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- W2893692955 date "2018-12-01" @default.
- W2893692955 modified "2023-10-15" @default.
- W2893692955 title "Synthesis and biological evaluation of substituted 3-(2′-benzimidazolyl)coumarin platinum(II) complexes as new telomerase inhibitors" @default.
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- W2893692955 doi "https://doi.org/10.1016/j.jinorgbio.2018.09.004" @default.
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